Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a
high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) …

Aging is the greatest risk factor for late-onset Alzheimer's disease (LOAD), which accounts
for> 95% of Alzheimer's disease (AD) cases. The mechanism underlying the aging-related …

Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA
and its derivatives have been used for many centuries due to their natural healing and …

Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

The physiological roles played by the tripeptide glutathione have greatly advanced over the
past decades superimposing the research on free radicals, oxidative stress and, more …

The antiporter system xc− imports the amino acid cystine, the oxidized form of cysteine, into
cells with a 1: 1 counter-transport of glutamate. It is composed of a light chain, xCT, and a …

Oxidative stress causes profound alterations of various biological structures, including
cellular membranes, lipids, proteins and nucleic acids, and it is involved in numerous …

Many local and systemic diseases especially diseases that are leading causes of death
globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart …

Diet is the only known intervention which has been conclusively shown to extend life span. It
can be argued the key role diet has to play in the aging process came to prominence as a …

Glutathione (GSH) is a ubiquitous intracellular peptide with diverse functions that include
detoxification, antioxidant defense, maintenance of thiol status, and modulation of cell …