Molecular genetics of infertility: loss-of-function mutations in humans and corresponding knockout/mutated mice
SY Jiao, YH Yang, SR Chen - Human reproduction update, 2021 - academic.oup.com
BACKGROUND Infertility is a major issue in human reproductive health, affecting an
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …
Disorders of spermatogenesis: perspectives for novel genetic diagnostics after 20 years of unchanged routine
F Tüttelmann, C Ruckert, A Röpke - Medizinische Genetik, 2018 - degruyter.com
Infertility is a common condition estimated to affect 10–15% of couples. The clinical causes
are attributed in equal parts to the male and female partners. Diagnosing male infertility …
are attributed in equal parts to the male and female partners. Diagnosing male infertility …
X-Linked TEX11 Mutations, Meiotic Arrest, and Azoospermia in Infertile Men
AN Yatsenko, AP Georgiadis, A Röpke… - … England Journal of …, 2015 - Mass Medical Soc
Background The genetic basis of nonobstructive azoospermia is unknown in the majority of
infertile men. Methods We performed array comparative genomic hybridization testing in …
infertile men. Methods We performed array comparative genomic hybridization testing in …
Genetics of male infertility: from research to clinic
Male infertility is a multifactorial complex disease with highly heterogeneous phenotypic
representation and in at least 15% of cases, this condition is related to known genetic …
representation and in at least 15% of cases, this condition is related to known genetic …
The evolving role of genetic tests in reproductive medicine
F Cariati, V D'Argenio, R Tomaiuolo - Journal of translational medicine, 2019 - Springer
Infertility is considered a major public health issue, and approximately 1 out of 6 people
worldwide suffer from infertility during their reproductive lifespans. Thanks to technological …
worldwide suffer from infertility during their reproductive lifespans. Thanks to technological …
The genetics of infertility: current status of the field
M Zorrilla, AN Yatsenko - Current genetic medicine reports, 2013 - Springer
Infertility is a relatively common health condition, affecting nearly 7% of all couples.
Clinically, it is a highly heterogeneous pathology with a complex etiology that includes …
Clinically, it is a highly heterogeneous pathology with a complex etiology that includes …
Monogenic causes of non-obstructive azoospermia: challenges, established knowledge, limitations and perspectives
It is estimated that one in 100 men have azoospermia, the complete lack of sperm in the
ejaculate. Currently,~ 20% of azoospermia cases remain idiopathic. Non-obstructive …
ejaculate. Currently,~ 20% of azoospermia cases remain idiopathic. Non-obstructive …
[HTML][HTML] Molecular control of rodent spermatogenesis
Spermatogenesis is a complex developmental process that ultimately generates mature
spermatozoa. This process involves a phase of proliferative expansion, meiosis, and …
spermatozoa. This process involves a phase of proliferative expansion, meiosis, and …
[HTML][HTML] Genetic causes of spermatogenic failure
A Massart, W Lissens, H Tournaye… - Asian journal of …, 2012 - ncbi.nlm.nih.gov
Abstract Approximately 10%–15% of couples are infertile, and a male factor is involved in
almost half of these cases. This observation is due in part to defects in spermatogenesis …
almost half of these cases. This observation is due in part to defects in spermatogenesis …
[HTML][HTML] Experimental methods to preserve male fertility and treat male factor infertility
Infertility is a prevalent condition that has insidious impacts on the infertile individuals, their
families, and society, which extend far beyond the inability to have a biological child …
families, and society, which extend far beyond the inability to have a biological child …