Nitrosamine contamination in pharmaceuticals: threat, impact, and control
B Tuesuwan, V Vongsutilers - Journal of Pharmaceutical Sciences, 2021 - Elsevier
Nitrosamine-contaminated medicinal products have raised safety concerns towards the use
of various drugs, not only valsartan and all tetrazole-containing angiotensin II receptor …
of various drugs, not only valsartan and all tetrazole-containing angiotensin II receptor …
Pathways for N-Nitroso Compound Formation: Secondary Amines and Beyond
R López-Rodríguez, JA McManus… - … Process Research & …, 2020 - ACS Publications
Recent drug recalls (eg, valsartan and ranitidine) linked to the discovery of nitrosamine
impurities have led to increased regulatory scrutiny in the manufacturing process of …
impurities have led to increased regulatory scrutiny in the manufacturing process of …
N-Methylation of Amines with Methanol in the Presence of Carbonate Salt Catalyzed by a Metal–Ligand Bifunctional Ruthenium Catalyst [(p-cymene) Ru (2, 2′-bpyO) …
P Liu, NT Tung, X Xu, J Yang, F Li - The Journal of Organic …, 2021 - ACS Publications
A ruthenium complex [(p-cymene) Ru (2, 2′-bpyO)(H2O)] was found to be a general and
efficient catalyst for the N-methylation of amines with methanol in the presence of carbonate …
efficient catalyst for the N-methylation of amines with methanol in the presence of carbonate …
An efficient synthesis of N-nitrosamines under solvent, metal and acid free conditions using tert-butyl nitrite
Synthesis of various N-nitroso compounds from secondary amines is reported using tert-
butyl nitrite (TBN) under solvent free conditions. Broad substrate scope, metal and acid free …
butyl nitrite (TBN) under solvent free conditions. Broad substrate scope, metal and acid free …
N-Methylation of amines with methanol in aqueous solution catalyzed by a water-soluble metal–ligand bifunctional dinuclear iridium catalyst
The N-methylation of amines with methanol in aqueous solution was proposed and
accomplished by using a water-soluble metal–ligand bifunctional dinuclear iridium catalyst …
accomplished by using a water-soluble metal–ligand bifunctional dinuclear iridium catalyst …
Recyclable covalent triazine framework-supported iridium catalyst for the N-methylation of amines with methanol in the presence of carbonate
P Liu, J Yang, Y Ai, S Hao, X Chen, F Li - Journal of Catalysis, 2021 - Elsevier
Abstract An iridium complex Cp* Ir@ CTF, which is synthesized by the coordinative
immobilization of [Cp* IrCl 2] 2 on a functionalized covalent triazine framework (CTF), was …
immobilization of [Cp* IrCl 2] 2 on a functionalized covalent triazine framework (CTF), was …
[HTML][HTML] Relating algal-derived extracellular and intracellular dissolved organic nitrogen with nitrogenous disinfection by-product formation
The dissolved organic nitrogen (DON) pool from algal-derived extracellular and intracellular
organic matter (EOM and IOM) comprises proteins, peptides, free amino acids and …
organic matter (EOM and IOM) comprises proteins, peptides, free amino acids and …
N-Nitrosamide chemistry: Synthesis and applications in organic transformations
Nitroso chemistry has gained considerable interest in the fields of chemistry and biology
over the past few decades. However, while N-nitrosamines and C-nitrosamines have been …
over the past few decades. However, while N-nitrosamines and C-nitrosamines have been …
Highly selective sp3 C–N bond activation of tertiary anilines modulated by steric and thermodynamic factors
X Jia, P Li, Y Shao, Y Yuan, H Ji, W Hou, X Liu… - Green …, 2017 - pubs.rsc.org
A highly selective sp3 C–N cleavage of tertiary anilines was achieved using the
TBN/TEMPO catalyst system. When N, N-diaklylanilines (alkyl, benzyl) were employed, the …
TBN/TEMPO catalyst system. When N, N-diaklylanilines (alkyl, benzyl) were employed, the …
PIFA-Promoted, Solvent-Controlled Selective Functionalization of C(sp2)–H or C(sp3)–H: Nitration via C–N Bond Cleavage of CH3NO2, Cyanation, or Oxygenation …
C Mudithanapelli, LP Dhorma, M Kim - Organic letters, 2019 - ACS Publications
A novel nitration (via C (sp3)–N breaking/C (sp2)–N formation with CH3NO2) mediated by
[bis (trifluoroacetoxy) iodo] benzene (PIFA) is described. The NO2 transfer from CH3NO2 to …
[bis (trifluoroacetoxy) iodo] benzene (PIFA) is described. The NO2 transfer from CH3NO2 to …