Tuberculosis drug discovery: challenges and new horizons
GFS Fernandes, AM Thompson… - Journal of Medicinal …, 2022 - ACS Publications
Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …
Isoniazid derivatives and their anti-tubercular activity
YQ Hu, S Zhang, F Zhao, C Gao, LS Feng, ZS Lv… - European journal of …, 2017 - Elsevier
Tuberculosis (TB), which has been a scourge of humanity for thousands of years, is a
worldwide pandemic disease caused mainly by Mycobacterium tuberculosis (MTB). The …
worldwide pandemic disease caused mainly by Mycobacterium tuberculosis (MTB). The …
Progress in the chemistry of nitrogen-, oxygen-and sulfur-containing heterocyclic systems
NN Makhova, LI Belen'kii, GA Gazieva… - Russian Chemical …, 2020 - iopscience.iop.org
The review is devoted to modern trends in the chemistry of nitrogen-, oxygen-and sulfur-
containing monocyclic, polynuclear and benzo (hetero) annulated heterocyclic compounds …
containing monocyclic, polynuclear and benzo (hetero) annulated heterocyclic compounds …
Anti-tuberculosis activity and its structure-activity relationship (SAR) studies of oxadiazole derivatives: A key review
With the increasing number of cases of inactive and drug-resistance tuberculosis, there is an
urgent need to develop new potent molecules set for fighting this brutal disease. Medicinal …
urgent need to develop new potent molecules set for fighting this brutal disease. Medicinal …
Nitric oxide in the pathogenesis and treatment of tuberculosis
H Jamaati, E Mortaz, Z Pajouhi, G Folkerts… - Frontiers in …, 2017 - frontiersin.org
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is globally
known as one of the most important human pathogens. Mtb is estimated to infect nearly one …
known as one of the most important human pathogens. Mtb is estimated to infect nearly one …
Molecular hybridization tools in the development of furoxan‐based NO‐donor prodrugs
LL Fershtat, NN Makhova - ChemMedChem, 2017 - Wiley Online Library
The molecular hybridization of different compounds with known pharmacological activity is a
particularly prominent approach for the design of potential drugs with improved …
particularly prominent approach for the design of potential drugs with improved …
Recent advancements and developments in search of anti-tuberculosis agents: a quinquennial update and future directions
Tuberculosis (TB) has been considered as the highly chronic, contagious and infectious
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …
Recent advances in the synthesis and biomedical applications of heterocyclic NO-donors
LL Fershtat, ES Zhilin - Molecules, 2021 - mdpi.com
Nitric oxide (NO) is a key signaling molecule that acts in various physiological processes
such as cellular metabolism, vasodilation and transmission of nerve impulses. A wide …
such as cellular metabolism, vasodilation and transmission of nerve impulses. A wide …
Oxadiazole scaffolds in anti-tuberculosis drug discovery
With the increasing number of cases of latent and drug resistant tuberculosis, there is an
urgent need to develop new, potent molecules capable of combating this deadly disease …
urgent need to develop new, potent molecules capable of combating this deadly disease …
Recent developments on synthesis strategies, SAR studies and biological activities of β-Carboline derivatives–an update
The β-carboline skeleton is prevalent in a vast collection of naturally present alkaloids. Most
of these alkaloids and their derivatives have been found to show significant biological …
of these alkaloids and their derivatives have been found to show significant biological …