MIC-1/GDF15 is a stress response cytokine and a distant member of the transforming growth
factor beta (TGFb) superfamily, with no close relatives. It acts via a recently identified …

GDF15 is a cell activation and stress response cytokine of the glial cell line–derived
neurotrophic factor family within the TGF-β superfamily. It acts through a recently identified …

Abstract GDF-15 (also MIC-1, NAG-1, PLAB, PTGFB) is a member of the TGF-β superfamily,
which is widely distributed in mammalian tissues and has been shown to play multiple roles …

Abstract Growth differentiation factor 15 (GDF15) is a divergent member of the transforming
growth factor β family discovered in a broad range of cells, as indicated by the diversity of its …

Growth differentiation factor-15 (GDF15) is a member of the GDF subfamily with potential
kidney protective functions. Here, we explored the impact of GDF15 on the expression of the …

The TGF-b superfamily cytokine MIC-1/GDF15 circulates in all humans and when
overproduced in cancer leads to anorexia/cachexia, by direct action on brain feeding …

Background Cancer associated cachexia affects the majority of cancer patients during the
course of the disease and thought to be directly responsible for about a quarter of all cancer …

Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in
multiple biological processes, including energy homeostasis, body weight regulation, and …

Initially considered as a macrophage inhibitor (macrophage inhibitory cytokine-1), growth
differentiation factor 15 (GDF-15) has been identified as a pleiotropic protein that plays key …

The majority of acute cardiovascular events (CVE) in patients are caused by occlusive
thrombosis because of rupture or erosion of atherosclerotic plaques. 1 Growth differentiation …