Significance: After approximatelty three decades of research, two Mn (III) porphyrins (MnPs),
MnTE-2-PyP5+ (BMX-010, AEOL10113) and MnTnBuOE-2-PyP5+ (BMX-001), have …

Significance: Cancer cells that are resistant to radiation and chemotherapy are a major
problem limiting the success of cancer therapy. Aggressive cancer cells depend on elevated …

Mn (III) ortho-N-alkyl-and N-alkoxyalkyl porphyrins (MnPs) were initially developed as
superoxide dismutase (SOD) mimics. These compounds were later shown to react with …

Radiation therapy (RT) is commonly used for the treatment of localized prostate cancer
(PCa). However, cancer cells often develop resistance to radiation through unknown …

Sickle cell disease (SCD) is an inherited monogenic disorder and the most common severe
hemoglobinopathy in the world. SCD is characterized by a point mutation in the β-globin …

Avasopasem manganese (AVA or GC4419), a selective superoxide dismutase mimetic, is in
a phase 3 clinical trial (NCT03689712) as a mitigator of radiation-induced mucositis in head …

Tumor hypoxia is a major mechanism of resistance to radiation therapy (RT), which is
associated with poor prognosis in affected cancer patients. Various approaches to treat …

The history of metalloporphyrins dates back more than 200 years ago. Metalloporphyrins are
excellent catalysts, capable of forming supramolecular systems, participate in oxygen …

Symptomatic normal tissue injury is a common side effect following definitive therapeutic
radiation and chemotherapy treatment for a variety of malignancies. These cancer therapy …

Although efficacy of combined histone deacetylase (HDAC) inhibitors and conventional
photon radiotherapy is being tested in clinical trials, their combined effect with proton beam …