The centrosome was discovered in the late 19th century when mitosis was first described.
Long recognized as a key organelle of the spindle pole, its core component, the centriole …

Cell polarity is defined as asymmetry in cell shape, protein distributions and cell functions. It
is characteristic of single-cell organisms, including yeast and bacteria, and cells in tissues of …

We report that eight heterozygous missense mutations in TUBB3, encoding the neuron-
specific β-tubulin isotype III, result in a spectrum of human nervous system disorders that we …

Cell Movements vividly describes how complex movements can arise from the properties
and behaviors of biological molecules. This second edition is updated throughout with …

Dynein at the cortex contributes to microtubule-based positioning processes such as spindle
positioning during embryonic cell division and centrosome positioning during fibroblast …

The spatial organization of cells depends on their ability to sense their own shape and size.
Here, we investigate how cell shape affects the positioning of the nucleus, spindle and …

The genetic causes of malformations of cortical development (MCD) remain largely
unknown. Here we report the discovery of multiple pathogenic missense mutations in …

Abstract Development of a multicellular organism from a fertilized egg depends on a precise
balance between symmetric cell divisions to expand the pool of similar cells, and …

The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the
model organism S. cerevisiae. Research performed during the past decade has significantly …

The microtubule-organizing center (MTOC) is reoriented between the nucleus and the
leading edge in many migrating cells and contributes to directional migration. Models …