Excessive alcohol consumption leads to damage to the organs of the body. More
importantly, the liver is majorly affected organ upon alcohol consumption for most of the …

Chronic alcohol consumption perturbs lipid metabolism as it increases adipose tissue
lipolysis and leads to ectopic fat deposition within the liver and the development of alcoholic …

Disordered lipid accumulation in the arterial wall is a hallmark of atherosclerosis. Previous
studies found that the expression of triggering receptor expressed on myeloid cells 2 …

Consumption of alcohol (ethanol) in various forms has been an integral part of human
civilization. Since ages, it also has been an important cause of death and health impairment …

According to data from the World Health Organization, there were about 3 million deaths
caused by alcohol consumption worldwide in 2016, of which about 50% were related to liver …

In the current scenario, prolonged consumption of alcohol across the globe is upsurging an
appreciable number of patients with the risk of alcohol-associated liver diseases. According …

Seven in absentia homolog 1 (Siah1) is one of the E3 ubiquitin ligases and plays a key role
in regulating target protein degradation. This study was designed to test the hypothesis that …

Non‐alcoholic fatty liver disease (NAFLD) and alcohol‐associated liver disease (ALD)
represent a spectrum of injury, ranging from simple steatosis to steatohepatitis and cirrhosis …

The pathogenesis of nonalcoholic steatohepatitis (NASH) is a two-stage process in which
steatosis is the “first hit” and an unknown “second hit.” We hypothesized that “a binge” could …

Chronic excessive alcohol use is a well-recognized risk factor for pancreatic dysfunction and
pancreatitis development. Evidence from in vivo and in vitro studies indicates that the …