Parasite and host erythrocyte kinomics of Plasmodium infection

J Adderley, T Williamson, C Doerig - Trends in Parasitology, 2021 - cell.com
Malaria remains a heavy public health and socioeconomic burden in tropical and
subtropical regions. Increasing resistance against front-line treatments implies that novel …

A framework for signaling throughout the life cycle of Babesia species

B Elsworth, MT Duraisingh - Molecular microbiology, 2021 - Wiley Online Library
Babesia species are tick‐borne intracellular parasites that infect the red blood cells of their
mammalian host, leading to severe or fatal disease. Babesia spp. infect a wide range of …

Plasmodial kinase inhibitors: license to cure?

DG Cabrera, A Horatscheck, CR Wilson… - Journal of Medicinal …, 2018 - ACS Publications
Advances in the genetics, function, and stage-specificity of Plasmodium kinases has driven
robust efforts to identify targets for the design of antimalarial therapies. Reverse genomics …

Flp/FRT-mediated disruption of ptex150 and exp2 in Plasmodium falciparum sporozoites inhibits liver-stage development

R McConville, JMM Krol, RWJ Steel… - Proceedings of the …, 2024 - National Acad Sciences
Plasmodium falciparum causes severe malaria and assembles a protein translocon (PTEX)
complex at the parasitophorous vacuole membrane (PVM) of infected erythrocytes, through …

Transcriptional heterogeneity and tightly regulated changes in gene expression during Plasmodium berghei sporozoite development

HN Bogale, TV Pascini, S Kanatani… - Proceedings of the …, 2021 - National Acad Sciences
Despite the critical role of Plasmodium sporozoites in malaria transmission, we still know
little about the mechanisms underlying their development in mosquitoes. Here, we use …

[HTML][HTML] Inflammatory response triggered by avian hepatitis E virus in vivo and in vitro

Y Zhang, Z Chi, Z Cui, S Chang, Y Wang… - Frontiers in …, 2023 - frontiersin.org
Hepatitis E virus (HEV) is relevant to public health worldwide, and it affects a variety of
animals. Big liver and spleen disease (BLS) and hepatitis-splenomegaly syndrome (HSS) …

Identification of essential exported Plasmodium falciparum protein kinases in malaria‐infected red blood cells

G Siddiqui, NI Proellochs… - British Journal of …, 2020 - Wiley Online Library
FIKK kinases in the human malaria parasite Plasmodium falciparum are attractive targets for
new anti‐malaria drugs, as they have no orthologues in humans and have been linked to …

FIKK kinase, a Ser/Thr kinase important to malaria parasites, is inhibited by tyrosine kinase inhibitors

BC Lin, DR Harris, LMD Kirkman, AM Perez, Y Qian… - ACS …, 2017 - ACS Publications
A relatively high-affinity inhibitor of FIKK kinase from the malaria parasite Plasmodium vivax
was identified by in vitro assay of recombinant kinase. The FIKK kinase family is unique to …

Post-Translational Modifications of Proteins of Malaria Parasites during the Life Cycle

E Schwarzer, O Skorokhod - International Journal of Molecular Sciences, 2024 - mdpi.com
Post-translational modifications (PTMs) are essential for regulating protein functions,
influencing various fundamental processes in eukaryotes. These include, but are not limited …

The anthraquinone emodin inhibits the non-exported FIKK kinase from Plasmodium falciparum

BC Lin, DR Harris, LMD Kirkman, AM Perez, Y Qian… - Bioorganic …, 2017 - Elsevier
The FIKK family of kinases is unique to parasites of the Apicomplexan order, which includes
all malaria parasites. Plasmodium falciparum, the most virulent form of human malaria, has a …