Capping protein (CP) binds the fast growing barbed end of the actin filament and regulates
actin assembly by blocking the addition and loss of actin subunits. Recent studies provide …

Cells use the actin cytoskeleton for many of their functions, including their division,
adhesion, mechanosensing, endo-and phagocytosis, migration, and invasion. Actin bundles …

We present an updated and integrated version of our widely used protein–protein docking
and binding affinity benchmarks. The benchmarks consist of non-redundant, high-quality …

The barbed and pointed ends of the actin filament (F-actin) are the sites of growth and
shrinkage and the targets of capping proteins that block subunit exchange, including CapZ …

The tubular endolysosomal network is a quality control system that ensures the proper
delivery of internalized receptors to specific subcellular destinations in order to maintain …

Endosomal protein sorting governs the fate of many physiologically important proteins
involved in a panoply of cellular functions. Recent discoveries have revealed a vital role for …

Retrograde transport from endosomes to the trans-Golgi network (TGN) diverts proteins and
lipids away from lysosomal degradation. It is essential for maintaining cellular homeostasis …

Cell motility and actin homeostasis depend on the control of polarized growth of actin
filaments. Profilin, an abundant regulator of actin dynamics, supports filament assembly at …

How cells simultaneously assemble actin structures of distinct sizes, shapes, and
filamentous architectures is still not well understood. Here, we used budding yeast as a …

Actin cytoskeleton remodeling, which drives changes in cell shape and motility, is
orchestrated by a coordinated control of polarized assembly of actin filaments. Signal …