Inflammatory aspects of Alzheimer's disease

P Botella Lucena, MT Heneka - Acta Neuropathologica, 2024 - Springer
Alzheimer´ s disease (AD) stands out as the most common chronic neurodegenerative
disorder. AD is characterized by progressive cognitive decline and memory loss, with …

Chronological versus immunological aging: Immune rejuvenation to arrest cognitive decline

L Basurco, MA Abellanas, M Purnapatre, P Antonello… - Neuron, 2024 - cell.com
The contemporary understanding that the immune response significantly supports higher
brain functions has emphasized the notion that the brain's condition is linked in a complex …

[HTML][HTML] Haploinsufficiency and Alzheimer's Disease: The Possible Pathogenic and Protective Genetic Factors

E Bagyinszky, SSA An - International Journal of Molecular Sciences, 2024 - mdpi.com
Alzheimer's disease (AD) is a complex neurodegenerative disorder influenced by various
genetic factors. In addition to the well-established amyloid precursor protein (APP) …

Roflumilast Attenuates Microglial Senescence and Retinal Inflammatory Neurodegeneration Post Retinal Ischemia Reperfusion Injury Through Inhibiting NLRP3 …

C Ou, Y Lin, J Wen, H Zhang, Y Xu… - … & Visual Science, 2024 - iovs.arvojournals.org
Purpose: Retinal ischemia-reperfusion (RIR) injury is implicated in various retinal diseases,
leading to retinal ganglion cells (RGCs) degeneration. Microglial senescence exacerbates …

[HTML][HTML] TREM1—Microglia crosstalk: Neurocognitive Disorders

H Li, W Yu, X Zheng, Z Zhu - Brain Research Bulletin, 2024 - Elsevier
Abstract Neurocognitive Disorders (NCDs) primarily affect cognitive functions, including
learning, memory, perception, and problem-solving. They predominantly arise as …

[PDF][PDF] A Comparative Study of Unveiling Strategies of Stem Cell Therapy for Neurodegenerative Diseases

KS Fatima, M Sinha - ijeasm.com
Neurodegenerative diseases pose significant challenges to healthcare systems worldwide,
with limited treatment options and no cure currently available. Stem cell therapy has …

Boosting peripheral immunity to fight neurodegeneration in the brain

M Schwartz, SP Colaiuta - Trends in Immunology, 2024 - cell.com
Reciprocal communication between the brain and the immune system is essential for
maintaining lifelong brain function. This interaction is mediated, at least in part, by immune …