Bidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies

J Stöhr, J Barbaresko, M Neuenschwander… - Scientific Reports, 2021 - nature.com
Periodontal disease has been reported to be associated with diabetes mellitus. However,
the direction of the association and the influence of bias are not clear. Thus, the aim of this …

100 years of insulin: celebrating the past, present and future of diabetes therapy

EK Sims, ALJ Carr, RA Oram, LA DiMeglio… - Nature medicine, 2021 - nature.com
The year 2021 marks the centennial of Banting and Best's landmark description of the
discovery of insulin. This discovery and insulin's rapid clinical deployment effectively …

[HTML][HTML] The role of inflammation in diabetes: current concepts and future perspectives

S Tsalamandris, AS Antonopoulos… - European cardiology …, 2019 - ncbi.nlm.nih.gov
Diabetes is a complex metabolic disorder affecting the glucose status of the human body.
Chronic hyperglycaemia related to diabetes is associated with end organ failure. The clinical …

Exercise and metabolic health: beyond skeletal muscle

JP Thyfault, A Bergouignan - Diabetologia, 2020 - Springer
Regular exercise is a formidable regulator of insulin sensitivity and overall systemic
metabolism through both acute events driven by each exercise bout and through chronic …

[HTML][HTML] The PI3K/AKT pathway in obesity and type 2 diabetes

X Huang, G Liu, J Guo, Z Su - International journal of biological …, 2018 - ncbi.nlm.nih.gov
Obesity and type 2 diabetes mellitus are complicated metabolic diseases that affect multiple
organs and are characterized by hyperglycaemia. Currently, stable and effective treatments …

Pathophysiology, phenotypes and management of type 2 diabetes mellitus in Indian and Chinese populations

C Ke, KMV Narayan, JCN Chan, P Jha… - Nature Reviews …, 2022 - nature.com
Nearly half of all adults with type 2 diabetes mellitus (T2DM) live in India and China. These
populations have an underlying predisposition to deficient insulin secretion, which has a key …

[HTML][HTML] Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus

MS Burhans, DK Hagman, JN Kuzma… - Comprehensive …, 2018 - ncbi.nlm.nih.gov
The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

Effects of diet, lifestyle, chrononutrition and alternative dietary interventions on postprandial glycemia and insulin resistance

E Papakonstantinou, C Oikonomou, G Nychas… - Nutrients, 2022 - mdpi.com
As years progress, we are found more often in a postprandial than a postabsorptive state.
Chrononutrition is an integral part of metabolism, pancreatic function, and hormone …

Obesity as a disease

J Upadhyay, O Farr, N Perakakis, W Ghaly… - Medical …, 2018 - medical.theclinics.com
Obesity is a complex, chronic medical condition with a major negative impact on human
health. 1 Over the last 30 years, there has been an exponential growth in the prevalence of …

[HTML][HTML] Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis

C Chen, CM Cohrs, J Stertmann, R Bozsak… - Molecular metabolism, 2017 - Elsevier
Background Plasma insulin levels are predominantly the product of the morphological mass
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …