Hemodynamic modeling, medical imaging, and machine learning and their applications to cardiovascular interventions

M Kadem, L Garber, M Abdelkhalek… - IEEE Reviews in …, 2022 - ieeexplore.ieee.org
Cardiovascular disease is a deadly global health crisis that carries a substantial financial
burden. Innovative treatment and management of cardiovascular disease straddles …

The Potential of Deep Learning to Advance Clinical Applications of Computational Biomechanics

GA Truskey - Bioengineering, 2023 - mdpi.com
When combined with patient information provided by advanced imaging techniques,
computational biomechanics can provide detailed patient-specific information about …

An ultrasound-exclusive non-invasive computational diagnostic framework for personalized cardiology of aortic valve stenosis

N Bahadormanesh, B Tomka, M Kadem… - Medical Image …, 2023 - Elsevier
Aortic stenosis (AS) is an acute and chronic cardiovascular disease and If left untreated,
50% of these patients will die within two years of developing symptoms. AS is characterized …

Impact of extra-anatomical bypass on coarctation fluid dynamics using patient-specific lumped parameter and Lattice Boltzmann modeling

R Sadeghi, B Tomka, S Khodaei, MA Daeian… - Scientific Reports, 2022 - nature.com
Accurate hemodynamic analysis is not only crucial for successful diagnosis of coarctation of
the aorta (COA), but intervention decisions also rely on the hemodynamics assessment in …

Impact of mixed valvular disease on coarctation hemodynamics using patient-specific lumped parameter and Lattice Boltzmann modeling

R Sadeghi, N Gasner, S Khodaei, J Garcia… - International Journal of …, 2022 - Elsevier
The optimal course of intervention for patients with coexisting coarctation of the aorta (COA)
and mixed valvular disease (combinations of aortic and mitral valve pathologies, MVD) is an …

Reducing long‐term mortality post transcatheter aortic valve replacement requires systemic differentiation of patient‐specific coronary hemodynamics

S Khodaei, L Garber, M Abdelkhalek… - Journal of the …, 2023 - Am Heart Assoc
Background Despite the proven benefits of transcatheter aortic valve replacement (TAVR)
and its recent expansion toward the whole risk spectrum, coronary artery disease is present …

Long-term prognostic impact of paravalvular leakage on coronary artery disease requires patient-specific quantification of hemodynamics

S Khodaei, L Garber, J Bauer, A Emadi… - Scientific Reports, 2022 - nature.com
Transcatheter aortic valve replacement (TAVR) is a frequently used minimally invasive
intervention for patient with aortic stenosis across a broad risk spectrum. While coronary …

Impact of TAVR on coronary artery hemodynamics using clinical measurements and image‐based patient‐specific in silico modeling

L Garber, S Khodaei, N Maftoon… - Scientific Reports, 2023 - nature.com
In recent years, transcatheter aortic valve replacement (TAVR) has become the leading
method for treating aortic stenosis. While the procedure has improved dramatically in the …

Reducing morbidity and mortality in patients with coarctation requires systematic differentiation of impacts of mixed valvular disease on coarctation hemodynamics

R Sadeghi, B Tomka, S Khodaei, J Garcia… - Journal of the …, 2022 - Am Heart Assoc
Background Despite ongoing advances in surgical techniques for coarctation of the aorta
(COA) repair, the long‐term results are not always benign. Associated mixed valvular …

Dynamic simulation of aortic valve stenosis using a lumped parameter cardiovascular system model with flow regime dependent valve pressure loss characteristics

R Laubscher, J van der Merwe, J Liebenberg… - Medical Engineering & …, 2022 - Elsevier
Valvular heart diseases are growing concern in impoverished parts of the world, such as
Southern-Africa, claiming more than 31% of total deaths related to cardiovascular diseases …