100 years of Mycobacterium bovis bacille Calmette-Guérin

C Lange, P Aaby, MA Behr, PR Donald… - The Lancet Infectious …, 2022 - thelancet.com
Summary Mycobacterium bovis bacille Calmette-Guérin (BCG), an experimental vaccine
designed to protect cattle from bovine tuberculosis, was administered for the first time to a …

[HTML][HTML] Non-specific effects of BCG vaccine on viral infections

S Moorlag, RJW Arts, R Van Crevel… - Clinical microbiology and …, 2019 - Elsevier
Abstract Background Some strains of Bacillus Calmette–Guérin (BCG) vaccine not only
confer protection against disseminated forms of tuberculosis, but also reduce all-cause …

Correlation between universal BCG vaccination policy and reduced morbidity and mortality for COVID-19: an epidemiological study

A Miller, MJ Reandelar, K Fasciglione, V Roumenova… - MedRxiv, 2020 - medrxiv.org
COVID-19 has spread to most countries in the world. Puzzlingly, the impact of the disease is
different in different countries. These differences are attributed to differences in cultural …

[PDF][PDF] BCG vaccination protects against experimental viral infection in humans through the induction of cytokines associated with trained immunity

RJW Arts, SJ Moorlag, B Novakovic, Y Li, SY Wang… - Cell host & …, 2018 - cell.com
The tuberculosis vaccine bacillus Calmette-Guérin (BCG) has heterologous beneficial
effects against non-related infections. The basis of these effects has been poorly explored in …

[HTML][HTML] 100 years of Bacillus Calmette–Guérin immunotherapy: from cattle to COVID-19

N Lobo, NA Brooks, AR Zlotta, JD Cirillo… - Nature Reviews …, 2021 - nature.com
Abstract Bacillus Calmette–Guérin (BCG) is the most widely used vaccine worldwide and
has been used to prevent tuberculosis for a century. BCG also stimulates an anti-tumour …

[HTML][HTML] Is global BCG vaccination‐induced trained immunity relevant to the progression of SARS‐CoV‐2 pandemic?

M Gursel, I Gursel - Allergy, 2020 - ncbi.nlm.nih.gov
2. IHME COVID-19 health service utilization forecasting team, Murray CJL. Forecasting
COVID-19 impact on hospital bed-days, ICU-days, ventilator days and deaths by US state in …

[PDF][PDF] Immunometabolic pathways in BCG-induced trained immunity

RJW Arts, A Carvalho, C La Rocca, C Palma… - Cell reports, 2016 - cell.com
The protective effects of the tuberculosis vaccine Bacillus Calmette-Guerin (BCG) on
unrelated infections are thought to be mediated by long-term metabolic changes and …

[HTML][HTML] BCG vaccination history associates with decreased SARS-CoV-2 seroprevalence across a diverse cohort of health care workers

MN Rivas, JE Ebinger, M Wu, N Sun… - The Journal of …, 2021 - Am Soc Clin Investig
BACKGROUND Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused more than 1 million deaths worldwide; thus, there is an urgent need to develop …

Vaccinology: time to change the paradigm?

CS Benn, AB Fisker, A Rieckmann, S Sørup… - The lancet infectious …, 2020 - thelancet.com
The existing vaccine paradigm assumes that vaccines only protect against the target
infection, that effective vaccines reduce mortality corresponding to the target infection's …

Association of BCG, DTP, and measles containing vaccines with childhood mortality: systematic review

JPT Higgins, K Soares-Weiser, JA López-López… - bmj, 2016 - bmj.com
Objectives To evaluate the effects on non-specific and all cause mortality, in children under
5, of Bacillus Calmette-Guérin (BCG), diphtheria-tetanus-pertussis (DTP), and standard titre …