In the past decade, evidence for a fluid clearance pathway in the central nervous system
known as the glymphatic system has grown. According to the glymphatic system concept …

The nature of fluid dynamics within the brain parenchyma is a focus of intensive research. Of
particular relevance is its participation in diseases associated with protein accumulation and …

Small vessel diseases (SVDs) are a group of disorders that result from pathological
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …

Immune privilege of the central nervous system (CNS) has been ascribed to the presence of
a blood–brain barrier and the lack of lymphatic vessels within the CNS parenchyma …

The meninges are the fibrous covering of the central nervous system (CNS) which contain
vastly heterogeneous cell types within its three layers (dura, arachnoid, and pia). The dural …

The classic concept of the absence of lymphatic vessels in the central nervous system
(CNS), suggesting the immune privilege of the brain in spite of its high metabolic rate, was …

Since its recent discovery, the meningeal lymphatic system has reshaped our understanding
of central nervous system (CNS) fluid exchange, waste clearance, immune cell trafficking …

Waste clearance (WC) is an essential process for brain homeostasis, which is required for
the proper and healthy functioning of all cerebrovascular and parenchymal brain cells. This …

Although the brain lacks conventional lymphatic vessels found in peripheral tissue, evidence
suggests that the space surrounding the vasculature serves a similar role in the clearance of …

An endothelial cell monolayer separates interstitia from blood and lymph, and determines
the bidirectional transfer of solutes and macromolecules across these biological spaces. We …