The incidence of liver cancer has increased in recent years. Worldwide, liver cancer is
common: more than 600000 related deaths are estimated each year. In the USA, about …

Fermentative glycolysis, an ancient evolved metabolic pathway, is exploited by rapidly
growing tissues and tumors but also occurs in response to the nutritional and energetic …

Backgrounds The role of sphere-forming culture in enriching subpopulations with stem-cell
properties in hepatocellular carcinoma (HCC) is unclear. The present study investigates its …

Lenvatinib is a long-awaited alternative to sorafenib for the first-line targeted therapy of
patients with advanced hepatocellular carcinoma (HCC). However, resistance to lenvatinib …

Solid tumors often suffer from suboptimal oxygen and nutrient supplies. This stress underlies
the requirement for metabolic adaptation. Aberrantly activated de novo lipogenesis is critical …

The mammalian gut microbiome (GM) plays a critical role in xenobiotic biotransformation
and can profoundly affect the toxic effects of xenobiotics. Previous in vitro studies have …

Smoothened (SMO) belongs to the Hedgehog (HH) signaling pathway, which regulates cell
growth, migration, invasion and stem cells in cancer. The HH signaling pathway includes …

The present study was designed to prepare Kaempferol loaded nanoparticles (KFP-Np) and
evaluate hepatoprotective and antioxidant effects in hepatocellular carcinoma models. KFP …

Hepatocellular carcinoma (HCC) is one of the most frequent and deadly malignancies
worldwide. Studies are urgently needed on its molecular pathogenesis and biological …

The complex and heterogeneous nature of hepatocellular carcinoma (HCC) hampers the
identification of effective therapeutic strategies. Cancer stem cells (CSCs) represent a …