Periodontitis is associated with hypertension: a systematic review and meta-analysis

E Munoz Aguilera, J Suvan, J Buti… - Cardiovascular …, 2020 - academic.oup.com
Recent evidence suggests a link between periodontitis (PD) and hypertension, but the
nature of this association remains unclear. The overall aim of this review was to critically …

Immune and inflammatory mechanisms in hypertension

TJ Guzik, R Nosalski, P Maffia… - Nature Reviews …, 2024 - nature.com
Hypertension is a global health problem, with> 1.3 billion individuals with high blood
pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension …

Endothelin: 30 years from discovery to therapy

M Barton, M Yanagisawa - Hypertension, 2019 - Am Heart Assoc
Discovered in 1987 as a potent endothelial cell–derived vasoconstrictor peptide, endothelin-
1 (ET-1), the predominant member of the endothelin peptide family, is now recognized as a …

Salt sensitivity: causes, consequences, and recent advances

MA Bailey, N Dhaun - Hypertension, 2024 - Am Heart Assoc
Salt (sodium chloride) is an essential nutrient required to maintain physiological functions.
However, for most people, daily salt intake far exceeds their physiological need and is …

Proteins from the DNA damage response: Regulation, dysfunction, and anticancer strategies

C Molinaro, A Martoriati, K Cailliau - Cancers, 2021 - mdpi.com
Simple Summary Cells respond to genotoxic stress through complex protein pathways
called DNA damage response (DDR). These mechanisms ensure the preservation of …

Role of drugs used for chronic disease management on susceptibility and severity of COVID‐19: a large case‐control study

H Yan, AM Valdes, A Vijay, S Wang… - Clinical …, 2020 - Wiley Online Library
This study aimed to investigate whether specific medications used in the treatment chronic
diseases affected either the development and/or severity of coronavirus disease 2019 …

Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria

W Nahrendorf, A Ivens, PJ Spence - Elife, 2021 - elifesciences.org
Immunity to malaria is often considered slow to develop but this only applies to defense
mechanisms that function to eliminate parasites (resistance). In contrast, immunity to severe …

Purification identification and function analysis of ACE inhibitory peptide from Ulva prolifera protein

Z Li, Y He, H He, W Zhou, M Li, A Lu, T Che, S Shen - Food Chemistry, 2023 - Elsevier
In the present study, Ulva prolifera, an edible alga, was used to prepare angiotensin-I
converting enzyme (ACE) inhibitory peptide. The algae protein was isolated and later …

Endothelin blockade prevents the long-term cardiovascular and renal sequelae of acute kidney injury in mice

A Czopek, R Moorhouse, PJ Gallacher… - Science Translational …, 2022 - science.org
Acute kidney injury (AKI) is common and associated with increased risks of cardiovascular
and chronic kidney disease. Causative molecular/physiological pathways are poorly …

The transcriptional landscape of pericytes in acute ischemic stroke

C Buizza, A Enström, R Carlsson, G Paul - Translational Stroke Research, 2024 - Springer
The current treatment options for ischemic stroke aim to achieve reperfusion but are time
critical. Novel therapeutic approaches that can be given beyond the limited time window of 3 …