Molecular mechanisms and physiological importance of circadian rhythms
A Patke, MW Young, S Axelrod - Nature reviews Molecular cell biology, 2020 - nature.com
To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …
behaviour and physiology, which include prominent behavioural states such as sleep–wake …
[HTML][HTML] Genomics of circadian rhythms in health and disease
F Rijo-Ferreira, JS Takahashi - Genome medicine, 2019 - Springer
Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …
processes. The central circadian clock exerts control over myriad aspects of mammalian …
Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans
The circadian clock modulates human physiology. However, the organization of tissue-
specific gene expression rhythms and how these depend on age and sex is not defined in …
specific gene expression rhythms and how these depend on age and sex is not defined in …
[HTML][HTML] Spatiotemporal metabolic liver zonation and consequences on pathophysiology
Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …
Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms
The circadian clock and feeding rhythms are both important regulators of rhythmic gene
expression in the liver. To further dissect the respective contributions of feeding and the …
expression in the liver. To further dissect the respective contributions of feeding and the …
Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms
The mammalian circadian clock, expressed throughout the brain and body, controls daily
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …
[HTML][HTML] NAD+ controls circadian reprogramming through PER2 nuclear translocation to counter aging
Disrupted sleep-wake and molecular circadian rhythms are a feature of aging associated
with metabolic disease and reduced levels of NAD+, yet whether changes in nucleotide …
with metabolic disease and reduced levels of NAD+, yet whether changes in nucleotide …
[HTML][HTML] Cross-species regulatory sequence activity prediction
DR Kelley - PLoS computational biology, 2020 - journals.plos.org
Machine learning algorithms trained to predict the regulatory activity of nucleic acid
sequences have revealed principles of gene regulation and guided genetic variation …
sequences have revealed principles of gene regulation and guided genetic variation …
Space-time logic of liver gene expression at sub-lobular scale
C Droin, JE Kholtei, K Bahar Halpern, C Hurni… - Nature …, 2021 - nature.com
The mammalian liver is a central hub for systemic metabolic homeostasis. Liver tissue is
spatially structured, with hepatocytes operating in repeating lobules, and sub-lobule zones …
spatially structured, with hepatocytes operating in repeating lobules, and sub-lobule zones …
Tissue-specific BMAL1 cistromes reveal that rhythmic transcription is associated with rhythmic enhancer–enhancer interactions
JR Beytebiere, AJ Trott, BJ Greenwell… - Genes & …, 2019 - genesdev.cshlp.org
The mammalian circadian clock relies on the transcription factor CLOCK: BMAL1 to
coordinate the rhythmic expression of thousands of genes. Consistent with the various …
coordinate the rhythmic expression of thousands of genes. Consistent with the various …