Fc-mediated antibody effector functions during respiratory syncytial virus infection and disease
EA Van Erp, W Luytjes, G Ferwerda… - Frontiers in …, 2019 - frontiersin.org
Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections
and hospitalization in infants under 1 year of age and there is currently no market-approved …
and hospitalization in infants under 1 year of age and there is currently no market-approved …
Fc receptors in antibody‐dependent enhancement of viral infections
Sensitization of the humoral immune response to invading viruses and production of
antiviral antibodies forms part of the host antiviral repertoire. Paradoxically, for a number of …
antiviral antibodies forms part of the host antiviral repertoire. Paradoxically, for a number of …
Viral-induced enhanced disease illness
MK Smatti, AA Al Thani, HM Yassine - Frontiers in microbiology, 2018 - frontiersin.org
Understanding immune responses to viral infections is crucial to progress in the quest for
effective infection prevention and control. The host immunity involves various mechanisms to …
effective infection prevention and control. The host immunity involves various mechanisms to …
Development of a humanized monoclonal antibody (MEDI-493) with potent in vitro and in vivo activity against respiratory syncytial virus
S Johnson, C Oliver, GA Prince… - Journal of Infectious …, 1997 - academic.oup.com
Neutralizing polyclonal antibody to respiratory syncytial virus (RSV) has been shown to be
an effective prophylactic agent when administered intravenously in high-risk infants. This …
an effective prophylactic agent when administered intravenously in high-risk infants. This …
Antibody‐dependent enhancement of viral infection: molecular mechanisms and in vivo implications
A Takada, Y Kawaoka - Reviews in medical virology, 2003 - Wiley Online Library
Besides the common receptor/coreceptor‐dependent mechanism of cellular attachment,
some viruses rely on antiviral antibodies for their efficient entry into target cells. This …
some viruses rely on antiviral antibodies for their efficient entry into target cells. This …
Antibody-dependent enhancement of viral infections
R Kulkarni - Dynamics of immune activation in viral diseases, 2020 - Springer
Antiviral antibodies constitute an important component of the host immune response against
viral infections and serve to neutralize and reduce infectivity of the virus. However, these …
viral infections and serve to neutralize and reduce infectivity of the virus. However, these …
A respiratory syncytial virus (RSV) F protein nanoparticle vaccine focuses antibody responses to a conserved neutralization domain
KA Swanson, JN Rainho-Tomko, ZP Williams… - Science …, 2020 - science.org
A stabilized form of the respiratory syncytial virus (RSV) fusion (F) protein has been explored
as a vaccine to prevent viral infection because it presents several potent neutralizing …
as a vaccine to prevent viral infection because it presents several potent neutralizing …
Respiratory syncytial virus
CB Hall - Principles and practice of clinical virology, 1999 - Wiley Online Library
Respiratory synctial virus (RSV) infections are a common and concerning conundrum. This
ubiquitous agent is the major respiratory pathogen of young children, with life‐threatening …
ubiquitous agent is the major respiratory pathogen of young children, with life‐threatening …
[HTML][HTML] Antibody-Dependent Enhancement (ADE) and the role of complement system in disease pathogenesis
Antibody-dependent enhancement (ADE) has been associated with severe disease
outcomes in several viral infections, including respiratory infections. In vitro and in vivo …
outcomes in several viral infections, including respiratory infections. In vitro and in vivo …
Antibody-dependent enhancement of dengue virus infection in primary human macrophages; balancing higher fusion against antiviral responses
J Flipse, MA Diosa-Toro, TE Hoornweg… - Scientific reports, 2016 - nature.com
The dogma is that the human immune system protects us against pathogens. Yet, several
viruses, like dengue virus, antagonize the hosts' antibodies to enhance their viral load and …
viruses, like dengue virus, antagonize the hosts' antibodies to enhance their viral load and …