Oocyte activation deficiency: a role for an oocyte contribution?
BACKGROUND Infertility affects between 10 and 16% of couples worldwide. Twenty to 30%
of cases of infertility are due to a male factor, 20–35% to a female factor, and 25–40% are …
of cases of infertility are due to a male factor, 20–35% to a female factor, and 25–40% are …
Total fertilization failure after ICSI: insights into pathophysiology, diagnosis, and management through artificial oocyte activation
G Campos, R Sciorio, SC Esteves - Human reproduction update, 2023 - academic.oup.com
BACKGROUND Total fertilization failure (TFF) is the failure of all metaphase II oocytes to
fertilize in ART cycles. The phenomenon represents a known cause of infertility, affecting 1 …
fertilize in ART cycles. The phenomenon represents a known cause of infertility, affecting 1 …
Good practice recommendations on add-ons in reproductive medicine
ESHRE Add-ons working group, K Lundin… - Human …, 2023 - academic.oup.com
STUDY QUESTION Which add-ons are safe and effective to be used in ART treatment?
SUMMARY ANSWER Forty-two recommendations were formulated on the use of add-ons in …
SUMMARY ANSWER Forty-two recommendations were formulated on the use of add-ons in …
Oocyte activation deficiency and assisted oocyte activation: mechanisms, obstacles and prospects for clinical application
BACKGROUND Oocyte activation deficiency (OAD) is attributed to the majority of cases
underlying failure of ICSI cycles, the standard treatment for male factor infertility. Oocyte …
underlying failure of ICSI cycles, the standard treatment for male factor infertility. Oocyte …
Novel phospholipase C zeta 1 mutations associated with fertilization failures after ICSI
M Torra-Massana, D Cornet-Bartolomé… - Human …, 2019 - academic.oup.com
Abstract STUDY QUESTION Are phospholipase C zeta 1 (PLCZ1) mutations associated with
fertilization failure (FF) after ICSI? SUMMARY ANSWER New mutations in the PLCZ1 …
fertilization failure (FF) after ICSI? SUMMARY ANSWER New mutations in the PLCZ1 …
Diagnosis and treatment of male infertility-related fertilization failure
A Cardona Barberán, A Boel… - Journal of clinical …, 2020 - mdpi.com
Infertility affects approximately 15% of reproductive-aged couples worldwide, of which up to
30% of the cases are caused by male factors alone. The origin of male infertility is mostly …
30% of the cases are caused by male factors alone. The origin of male infertility is mostly …
Assisted oocyte activation with calcium ionophore improves pregnancy outcomes and offspring safety in infertile patients: a systematic review and meta-analysis
Y Shan, H Zhao, D Zhao, J Wang, Y Cui… - Frontiers in Physiology, 2022 - frontiersin.org
This study aimed to evaluate the efficacy and safety of calcium ionophore during assisted
oocyte activation (AOA). This meta-analysis contained randomized controlled trials and …
oocyte activation (AOA). This meta-analysis contained randomized controlled trials and …
Novel mutations in PLCZ1 cause male infertility due to fertilization failure or poor fertilization
Z Yan, Y Fan, F Wang, Z Yan, M Li… - Human …, 2020 - academic.oup.com
STUDY QUESTION Do sperm-specific phospholipase C zeta (PLCZ1) mutations account for
male infertility due to fertilization failure? SUMMARY ANSWER Six novel mutations and one …
male infertility due to fertilization failure? SUMMARY ANSWER Six novel mutations and one …
[HTML][HTML] Effect of two assisted oocyte activation protocols used to overcome fertilization failure on the activation potential and calcium releasing pattern
D Nikiforaki, FV Meerschaut, C De Roo, Y Lu… - Fertility and sterility, 2016 - Elsevier
Objective To assess the effect of two assisted oocyte activation (AOA) protocols with the use
of two calcium (Ca 2+) ionophores, ionomycin and A23187 (calcimycin), on the intracellular …
of two calcium (Ca 2+) ionophores, ionomycin and A23187 (calcimycin), on the intracellular …
Expression of sperm PLCζ and clinical outcomes of ICSI-AOA in men affected by globozoospermia due to DPY19L2 deletion
M Tavalaee, M Nomikos, FA Lai… - Reproductive …, 2018 - Elsevier
Globozoospermia is characterized by the presence of 100% acrosomeless round-headed
spermatozoa in an ejaculate. Failed fertilization after intracytoplasmic sperm injection (ICSI) …
spermatozoa in an ejaculate. Failed fertilization after intracytoplasmic sperm injection (ICSI) …