BACKGROUND Infertility affects between 10 and 16% of couples worldwide. Twenty to 30%
of cases of infertility are due to a male factor, 20–35% to a female factor, and 25–40% are …

BACKGROUND Total fertilization failure (TFF) is the failure of all metaphase II oocytes to
fertilize in ART cycles. The phenomenon represents a known cause of infertility, affecting 1 …

STUDY QUESTION Which add-ons are safe and effective to be used in ART treatment?
SUMMARY ANSWER Forty-two recommendations were formulated on the use of add-ons in …

BACKGROUND Oocyte activation deficiency (OAD) is attributed to the majority of cases
underlying failure of ICSI cycles, the standard treatment for male factor infertility. Oocyte …

Abstract STUDY QUESTION Are phospholipase C zeta 1 (PLCZ1) mutations associated with
fertilization failure (FF) after ICSI? SUMMARY ANSWER New mutations in the PLCZ1 …

Infertility affects approximately 15% of reproductive-aged couples worldwide, of which up to
30% of the cases are caused by male factors alone. The origin of male infertility is mostly …

This study aimed to evaluate the efficacy and safety of calcium ionophore during assisted
oocyte activation (AOA). This meta-analysis contained randomized controlled trials and …

STUDY QUESTION Do sperm-specific phospholipase C zeta (PLCZ1) mutations account for
male infertility due to fertilization failure? SUMMARY ANSWER Six novel mutations and one …

Objective To assess the effect of two assisted oocyte activation (AOA) protocols with the use
of two calcium (Ca 2+) ionophores, ionomycin and A23187 (calcimycin), on the intracellular …

Globozoospermia is characterized by the presence of 100% acrosomeless round-headed
spermatozoa in an ejaculate. Failed fertilization after intracytoplasmic sperm injection (ICSI) …