The immunology of multiple sclerosis

KE Attfield, LT Jensen, M Kaufmann… - Nature Reviews …, 2022 - nature.com
Our incomplete understanding of the causes and pathways involved in the onset and
progression of multiple sclerosis (MS) limits our ability to effectively treat this complex …

Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis

MA Friese, B Schattling, L Fugger - Nature Reviews Neurology, 2014 - nature.com
Multiple sclerosis (MS) is the most frequent chronic inflammatory disease of the CNS, and
imposes major burdens on young lives. Great progress has been made in understanding …

Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data

MJ Zhang, K Hou, KK Dey, S Sakaue, KA Jagadeesh… - Nature …, 2022 - nature.com
Single-cell RNA sequencing (scRNA-seq) provides unique insights into the pathology and
cellular origin of disease. We introduce single-cell disease relevance score (scDRS), an …

Locus for severity implicates CNS resilience in progression of multiple sclerosis

MultipleMS Consortium Harroud Adil 1 78 78 Jónsdóttir … - Nature, 2023 - nature.com
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that
results in significant neurodegeneration in the majority of those affected and is a common …

[HTML][HTML] Changes in gut microbiota and multiple sclerosis: a systematic review

A Ordoñez-Rodriguez, P Roman… - International Journal of …, 2023 - mdpi.com
Introduction: Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease
mediated by autoimmune reactions against myelin proteins and gangliosides in the grey …

The genetics of multiple sclerosis: an up‐to‐date review

PA Gourraud, HF Harbo, SL Hauser… - Immunological …, 2012 - Wiley Online Library
Multiple sclerosis (MS) is a prevalent inflammatory disease of the central nervous system
that often leads to disability in young adults. Treatment options are limited and often only …

Genetics of multiple sclerosis: an overview and new directions

NA Patsopoulos - Cold Spring Harbor …, 2018 - perspectivesinmedicine.cshlp.org
The contribution of genetic inheritance in multiple sclerosis was established early on.
Although multiple sclerosis is not a Mendelian disease, its incidence and prevalence is …

Disability in multiple sclerosis: a reference for patients and clinicians

I Kister, E Chamot, AR Salter, GR Cutter, TE Bacon… - Neurology, 2013 - AAN Enterprises
Objective: To create a reference table of disability outcomes in multiple sclerosis (MS) that
would enable patients to rank their disability relative to others' with similar disease duration …

[HTML][HTML] The efficacy of cannabis on multiple sclerosis-related symptoms

F Haddad, G Dokmak, R Karaman - Life, 2022 - mdpi.com
Multiple sclerosis (MS) is known as an autoimmune disease that damages the neurons in
the central nervous system. MS is characterized by its most common symptoms of spasticity …

Age related multiple sclerosis severity score: disability ranked by age

A Manouchehrinia, H Westerlind… - Multiple Sclerosis …, 2017 - journals.sagepub.com
Background: The Multiple Sclerosis Severity Score (MSSS) is obtained by normalising the
Expanded Disability Status Scale (EDSS) score for disease duration and has been a …