Obesity, which is a worldwide epidemic, confers increased risk for multiple serious
conditions including type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular …

Sarcopenia, an age-associated decline in skeletal muscle mass coupled with functional
deterioration, may be exacerbated by obesity leading to higher disability, frailty, morbidity …

Physical exercise has beneficial effects on metabolic diseases, and a combined therapeutic
regimen of regular exercise and pharmaceutical treatment is often recommended for their …

Introduction Irisin is a myokine/adipokine induced by the exercise in mice and humans,
which is proposed to induce “browning” of white adipose tissue, its primary target, thus …

Irisin, out-membrane part of fibronectin type III domain–containing 5 protein (FNDC5), was
activated by Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) …

Irisin is an exercise-induced myokine expressed as a bioactive peptide in multiple tissues
and organs, and exercise and cold exposure are the major inducers for its secretion. Irisin …

Sedentary life style is considered to be an independent risk factor for many disorders,
including development of type 2 diabetes, obesity, immune dysfunction, asthma, and …

Obesity and type II diabetes are characterized by insulin resistance in peripheral tissues. A
high caloric intake combined with a sedentary lifestyle is the leading cause of these …

Rationale: The newly discovered myokine irisin has been proposed to affect obesity and
metabolism by promoting browning of white adipose tissue. However, clinical and functional …

Obesity-associated metabolic abnormalities comprise a cluster of conditions including
dyslipidemia, insulin resistance, diabetes and cardiovascular diseases that has affected …