Targeting the IL-6/JAK/STAT3 signalling axis in cancer
DE Johnson, RA O'Keefe, JR Grandis - Nature reviews Clinical …, 2018 - nature.com
Abstract The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer,
and such hyperactivation is generally associated with a poor clinical prognosis. In the …
and such hyperactivation is generally associated with a poor clinical prognosis. In the …
[HTML][HTML] The role of IL-6 in cancer cell invasiveness and metastasis—overview and therapeutic opportunities
M Rašková, L Lacina, Z Kejík, A Venhauerová… - Cells, 2022 - mdpi.com
Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various
homeostatic and pathological processes. These activities range from regulating embryonic …
homeostatic and pathological processes. These activities range from regulating embryonic …
The miRNA: a small but powerful RNA for COVID-19
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is a severe and rapidly evolving epidemic. Now …
syndrome coronavirus 2 (SARS-CoV-2) is a severe and rapidly evolving epidemic. Now …
[HTML][HTML] microRNA therapeutics in cancer—an emerging concept
MY Shah, A Ferrajoli, AK Sood, G Lopez-Berestein… - …, 2016 - thelancet.com
MicroRNAs (miRNAs) are an evolutionarily conserved class of small, regulatory non-coding
RNAs that negatively regulate protein coding gene and other non-coding transcripts …
RNAs that negatively regulate protein coding gene and other non-coding transcripts …
IL-6 and ovarian cancer: inflammatory cytokines in promotion of metastasis
L Browning, MR Patel, EB Horvath… - Cancer management …, 2018 - Taylor & Francis
Ovarian cancer is the most fatal gynecological cancer in the USA and the fifth most common
cancer-related cause of death in women. Inflammation has been shown to play many roles …
cancer-related cause of death in women. Inflammation has been shown to play many roles …
The circular RNA circPRKCI promotes tumor growth in lung adenocarcinoma
Somatic copy number variations (CNV) may drive cancer progression through both coding
and noncoding transcripts. However, noncoding transcripts resulting from CNV are largely …
and noncoding transcripts. However, noncoding transcripts resulting from CNV are largely …
[HTML][HTML] The miRNA–target interactions: An underestimated intricacy
MicroRNAs (miRNAs) play indispensable roles in posttranscriptional gene regulation. Their
cellular regulatory impact is determined not solely by their sheer number, which likely …
cellular regulatory impact is determined not solely by their sheer number, which likely …
[HTML][HTML] The potential and controversy of targeting STAT family members in cancer
Abstract The Signal Transducer and Activator of Transcription (STAT) family of proteins
consists of transcription factors that play a complex and essential role in the regulation of …
consists of transcription factors that play a complex and essential role in the regulation of …
miRNA profile in ovarian cancer
Ovarian cancer is a gynecological cancer with high mortality and a heterogeneous nature
which complicates its early detection and primary prevention. Numerous studies have …
which complicates its early detection and primary prevention. Numerous studies have …
The role of MiRNA in cancer: pathogenesis, diagnosis, and treatment
Cancer is also determined by the alterations of oncogenes and tumor suppressor genes.
These gene expressions can be regulated by microRNAs (miRNA). At this point, researchers …
These gene expressions can be regulated by microRNAs (miRNA). At this point, researchers …