The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

The development of T cells in the thymus involves several differentiation and proliferation
events, during which hematopoietic precursors give rise to T cells ready to respond to …

Notch proteins are cell surface receptors that mediate developmental cell specification
events. To explore the function of murine Notch1, an essential portion of the gene was …

Antigen receptor–controlled checkpoints in B lymphocyte development are crucial for the
prevention of autoimmune diseases such as systemic lupus erythematosus. Checkpoints at …

γδ T cells are the first T cell lineage to develop in the thymus and take up residence in a
wide variety of tissues where they can provide fast, innate-like sources of effector cytokines …

Murine T cell development begins with the generation of a unique Vγ5+ Vδ1+ epidermal γδ
T cell compartment and a unique, more broadly distributed Vγ6+ Vδ1+ subset that is an …

γδT cells are an unconventional population of T lymphocytes that play an indispensable role
in host defense, immune surveillance, and homeostasis of the immune system. They display …

The lymphocytes, T, B, and NK cells, and a proportion of dendritic cells (DCs) have a
common developmental origin. Lymphocytes develop from hematopoietic stem cells via …

We have recently reported that Notch 1, a member of the Notch multigene family, is essential
for the development of murine T cells. Using a mouse model in which Notch 1 is inactivated …

Signal transduction by the T-cell antigen receptor (TCR) is initiated by phosphorylation of
conserved motifs (ITAMs) contained within the cytoplasmic domains of the invariant …