Tunnels for protein export from the endoplasmic reticulum

I Raote, V Malhotra - Annual review of biochemistry, 2021 - annualreviews.org
The functions of coat protein complex II (COPII) coats in cargo packaging and the creation of
vesicles at the endoplasmic reticulum are conserved in eukaryotic protein secretion …

[HTML][HTML] Vesicle-mediated export from the ER: COPII coat function and regulation

JG D'Arcangelo, KR Stahmer, EA Miller - Biochimica et Biophysica Acta …, 2013 - Elsevier
Vesicle trafficking from the endoplasmic reticulum (ER) is a vital cellular process in all
eukaryotes responsible for moving secretory cargoes from the ER to the Golgi apparatus. To …

Sorting and export of proteins at the endoplasmic reticulum

I Raote, S Saxena, V Malhotra - Cold Spring Harbor …, 2023 - cshperspectives.cshlp.org
Secretory proteins are transported from the endoplasmic reticulum (ER) to the Golgi complex
in carriers that are formed by the concerted activities of cytoplasmic proteins in the coat …

Signalling to and from the secretory pathway

H Farhan, C Rabouille - Journal of cell science, 2011 - journals.biologists.com
For growth, survival, communication and homeostasis, cells transport a large number of
proteins to the plasma membrane and the extracellular medium by using the secretory …

TFG clusters COPII‐coated transport carriers and promotes early secretory pathway organization

A Johnson, N Bhattacharya, M Hanna… - The EMBO …, 2015 - embopress.org
In mammalian cells, cargo‐laden secretory vesicles leave the endoplasmic reticulum (ER)
en route to ER‐Golgi intermediate compartments (ERGIC) in a manner dependent on the …

TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER–Golgi intermediate compartments

MG Hanna IV, S Block, EB Frankel… - Proceedings of the …, 2017 - National Acad Sciences
The conserved coat protein complex II (COPII) mediates the initial steps of secretory protein
trafficking by assembling onto subdomains of the endoplasmic reticulum (ER) in two layers …

Amino Acid Transporter SLC6A14 (ATB0,+) – A Target in Combined Anti-cancer Therapy

KA Nałęcz - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Cancer cells are characterized by quick growth and proliferation, demanding constant
supply of various nutrients. Several plasma membrane transporters delivering such …

ERK7 is a negative regulator of protein secretion in response to amino‐acid starvation by modulating Sec16 membrane association

M Zacharogianni, V Kondylis, Y Tang, H Farhan… - The EMBO …, 2011 - embopress.org
RNAi screening for kinases regulating the functional organization of the early secretory
pathway in Drosophila S2 cells has identified the atypical Mitotic‐Associated Protein Kinase …

Vesicle-mediated ER export of proteins and lipids

AD Gillon, CF Latham, EA Miller - … et Biophysica Acta (BBA)-Molecular and …, 2012 - Elsevier
In eukaryotic cells, the endoplasmic reticulum (ER) is a major site of synthesis of both lipids
and proteins, many of which must be transported to other organelles. The COPII coat …

OLFM4, KNG1 and Sec24C identified by proteomics and immunohistochemistry as potential markers of early colorectal cancer stages

F Quesada-Calvo, C Massot, V Bertrand… - Clinical proteomics, 2017 - Springer
Background Despite recent advances in colorectal cancer (CRC) diagnosis and population
screening programs, the identification of patients with preneoplastic lesions or with early …