[HTML][HTML] Control of human toxoplasmosis
Toxoplasmosis is caused by Toxoplasma gondii, an apicomplexan parasite that is able to
infect any nucleated cell in any warm-blooded animal. Toxoplasma gondii infects around 2 …
infect any nucleated cell in any warm-blooded animal. Toxoplasma gondii infects around 2 …
Applications of CRISPR/Cas system to bacterial metabolic engineering
The clustered regularly interspaced short palindromic repeats/CRISPR-associated
(CRISPR/Cas) adaptive immune system has been extensively used for gene editing …
(CRISPR/Cas) adaptive immune system has been extensively used for gene editing …
A comprehensive subcellular atlas of the Toxoplasma proteome via hyperLOPIT provides spatial context for protein functions
Apicomplexan parasites cause major human disease and food insecurity. They owe their
considerable success to highly specialized cell compartments and structures. These …
considerable success to highly specialized cell compartments and structures. These …
Genome-wide screens identify Toxoplasma gondii determinants of parasite fitness in IFNγ-activated murine macrophages
Macrophages play an essential role in the early immune response against Toxoplasma and
are the cell type preferentially infected by the parasite in vivo. Interferon gamma (IFNγ) elicits …
are the cell type preferentially infected by the parasite in vivo. Interferon gamma (IFNγ) elicits …
A splitCas9 phenotypic screen in Toxoplasma gondii identifies proteins involved in host cell egress and invasion
W Li, J Grech, JF Stortz, M Gow, J Periz… - Nature …, 2022 - nature.com
Apicomplexan parasites, such as Toxoplasma gondii, have specific adaptations that enable
invasion and exit from the host cell. Owing to the phylogenetic distance between …
invasion and exit from the host cell. Owing to the phylogenetic distance between …
Genome-wide CRISPR screen identifies genes synthetically lethal with GRA17, a nutrient channel encoding gene in Toxoplasma
Toxoplasma gondii is a parasite that replicates within a specialized compartment called the
parasitophorous vacuole (PV), which is surrounded by the PV membrane (PVM). To obtain …
parasitophorous vacuole (PV), which is surrounded by the PV membrane (PVM). To obtain …
In vivo CRISPR screen identifies TgWIP as a Toxoplasma modulator of dendritic cell migration
Toxoplasma can reach distant organs, especially the brain, leading to a lifelong chronic
phase. However, genes involved in related in vivo processes are currently unknown. Here …
phase. However, genes involved in related in vivo processes are currently unknown. Here …
CRISPR Screens Identify Toxoplasma Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human Cells
Toxoplasma virulence depends on its ability to evade or survive the toxoplasmacidal
mechanisms induced by interferon gamma (IFNγ). While many Toxoplasma genes involved …
mechanisms induced by interferon gamma (IFNγ). While many Toxoplasma genes involved …
[HTML][HTML] A one health approach to vaccines against Toxoplasma gondii
EA Innes, C Hamilton, JL Garcia, A Chryssafidis… - Food and waterborne …, 2019 - Elsevier
Toxoplasmosis is a serious disease with global impact, now recognised as one of the most
important food borne diseases worldwide and a major cause of production loss in livestock …
important food borne diseases worldwide and a major cause of production loss in livestock …
Guide RNA modification as a way to improve CRISPR/Cas9-based genome-editing systems
J Filippova, A Matveeva, E Zhuravlev, G Stepanov - Biochimie, 2019 - Elsevier
Genome-editing technologies, in particular, CRISPR systems, are widely used for targeted
regulation of gene expression and obtaining modified human and animal cell lines, plants …
regulation of gene expression and obtaining modified human and animal cell lines, plants …