Preservatives in eyedrops: the good, the bad and the ugly

C Baudouin, A Labbé, H Liang, A Pauly… - Progress in retinal and …, 2010 - Elsevier
There is a large body of evidence from experimental and clinical studies showing that the
long-term use of topical drugs may induce ocular surface changes, causing ocular …

Pathogenesis of pterygia: role of cytokines, growth factors, and matrix metalloproteinases

N Di Girolamo, J Chui, MT Coroneo… - Progress in retinal and …, 2004 - Elsevier
Pterygium is a common ocular surface disease apparently only observed in humans.
Chronic UV exposure is a widely accepted aetiological factor in the pathogenesis of this …

Cell culture models of the ocular barriers

M Hornof, E Toropainen, A Urtti - European journal of pharmaceutics and …, 2005 - Elsevier
The presence of tight barriers, which regulate the environment of ocular tissues in the
anterior and posterior part of the eye, is essential for normal visual function. The …

Novel hyaluronic acid-chitosan nanoparticles for ocular gene therapy

M De la Fuente, B Seijo… - … ophthalmology & visual …, 2008 - iovs.arvojournals.org
purpose. Gene therapy offers a promising alternative for the treatment of ocular diseases.
However, the implementation of this type of therapy is actually hampered by the lack of an …

[HTML][HTML] Chitosan nanoparticles as a potential drug delivery system for the ocular surface: toxicity, uptake mechanism and in vivo tolerance

AE de Salamanca, Y Diebold, M Calonge… - … & visual science, 2006 - arvojournals.org
purpose. To study the in vitro and in vivo interaction of chitosan nanoparticles (CSNPs), a
new particulate drug carrier, with epithelial cells on the ocular surface. methods. CSNPs …

Ocular drug delivery by liposome–chitosan nanoparticle complexes (LCS-NP)

Y Diebold, M Jarrín, V Sáez, ELS Carvalho, M Orea… - Biomaterials, 2007 - Elsevier
This study evaluated in vitro and in vivo a colloidal nanosystem with the potential to deliver
drugs to the ocular surface. This nanosystem, liposome–chitosan nanoparticle complexes …

Membrane-tethered mucins have multiple functions on the ocular surface

B Govindarajan, IK Gipson - Experimental eye research, 2010 - Elsevier
Membrane-tethered mucins are large glycoproteins present in the glycocalyx along the
apical surface of all wet-surfaced epithelia of the body, including that of the ocular surface …

Sialic acid tissue distribution and influenza virus tropism

U Kumlin, S Olofsson, K Dimock… - Influenza and other …, 2008 - Wiley Online Library
Avian influenza A viruses exhibit a strong preference for using α2, 3‐linked sialic acid as a
receptor. Until recently, the presumed lack of this receptor in human airways was believed to …

Avian influenza and sialic acid receptors: more than meets the eye?

S Olofsson, U Kumlin, K Dimock… - The Lancet infectious …, 2005 - thelancet.com
Given our recent discoveries that the ocular human pathogens adenovirus serotype 37 and
enterovirus serotype 70 use sialic acid linked to galactose via α2, 3 glycosidic bonds as a …

Blue light phototoxicity toward human corneal and conjunctival epithelial cells in basal and hyperosmolar conditions

V Marek, S Mélik-Parsadaniantz, T Villette… - Free Radical Biology …, 2018 - Elsevier
Aims The ocular surface is the very first barrier between the visual system and external
environment. It protects the eye from the exposure to various light sources that significantly …