The hydrodynamic radii of macromolecules and their effect on red blood cell aggregation

JK Armstrong, RB Wenby, HJ Meiselman, TC Fisher - Biophysical journal, 2004 - cell.com
The effects of nonionic polymers on human red blood cell (RBC) aggregation were
investigated. The hydrodynamic radius (R h) of individual samples of dextran …

Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution

J Liu, MDH Nguyen, JD Andya, SJ Shire - Journal of pharmaceutical …, 2005 - Elsevier
This study was conducted to investigate the effect of reversible protein self-association on
the viscosity of concentrated monoclonal antibody solutions. The viscosities of the …

Factors affecting the viscosity in high concentration solutions of different monoclonal antibodies

S Yadav, SJ Shire, DS Kalonia - Journal of pharmaceutical sciences, 2010 - Elsevier
The viscosity profiles of four different IgG 1 molecules were studied as a function of
concentration at pH 6.0. At high concentrations, MAb-H and-A showed significantly higher …

Monoclonal antibody self-association, cluster formation, and rheology at high concentrations

WG Lilyestrom, S Yadav, SJ Shire… - The Journal of Physical …, 2013 - ACS Publications
The rheological properties of macromolecular and colloidal suspensions are dependent on
the thermodynamic and kinetic parameters that define viscous flow, and remain an active …

Binding of plasma proteins to titanium dioxide nanotubes with different diameters

M Kulkarni, A Flašker, M Lokar… - International journal …, 2015 - Taylor & Francis
Titanium and titanium alloys are considered to be one of the most applicable materials in
medical devices because of their suitable properties, most importantly high corrosion …

Construction, MD simulation, and hydrodynamic validation of an all-atom model of a monoclonal IgG antibody

JP Brandt, TW Patapoff, SR Aragon - Biophysical Journal, 2010 - cell.com
At 150 kDa, antibodies of the IgG class are too large for their structure to be determined with
current NMR methodologies. Because of hinge-region flexibility, it is difficult to obtain atomic …

Transport of the anti-diabetic VO2+ complexes formed by pyrone derivatives in the blood serum

D Sanna, L Bíró, P Buglyó, G Micera… - Journal of Inorganic …, 2012 - Elsevier
The biotransformation in the blood serum of the two anti-diabetic agents [VO (ema) 2]–or
BEOV–and [VO (koj) 2] formed by ethylmaltol (Hema) and kojic acid (Hkoj) was studied with …

Coarse-grained modeling of protein second osmotic virial coefficients: sterics and short-ranged attractions

A Grünberger, PK Lai, MA Blanco… - The Journal of Physical …, 2013 - ACS Publications
A series of coarse-grained models, with different levels of structural resolution, were tested
to calculate the steric contributions to protein osmotic second virial coefficients (B 22, S) for …

The solution structures of two human IgG1 antibodies show conformational stability and accommodate their C1q and FcγR ligands

LE Rayner, GK Hui, J Gor, RK Heenan… - Journal of Biological …, 2015 - ASBMB
The human IgG1 antibody subclass shows distinct properties compared with the IgG2, IgG3,
and IgG4 subclasses and is the most exploited subclass in therapeutic antibodies. It is the …

The solution conformations of the subclasses of human IgG deduced from sedimentation and small angle X-ray scattering studies

L Gregory, KG Davis, B Sheth, J Boyd, R Jefferis… - Molecular …, 1987 - Elsevier
The solution conformations of human immunoglobulin G subclass molecules have been
investigated by sedimentation and small-angle X-ray scattering techniques. Both methods …