Previous studies on genetic diseases predominantly focused on protein-coding variations,
overlooking the vast noncoding regions in the human genome. The development of high …

Osteogenesis imperfecta (OI) is a rare, hereditary connective tissue disorder, clinically
characterized by bone fragility, bone deformities, and small stature that can be accompanied …

The formation of functional bone requires a delicate interplay between osteogenesis and
osteolysis. Disturbances in this subtle balance result in an increased risk for fractures …

ANTXR1 is one of two cell surface receptors mediating the uptake of the anthrax toxin into
cells. Despite substantial research on its role in anthrax poisoning and a proposed function …

In this chapter, we review the current knowledge about the complex intracellular
biosynthesis, secretion, and extracellular maturation of collagen I. We focus on the specific …

ABSTRACT RNA polymerase II (Pol II) regulation during early elongation has emerged as a
regulatory hub in the gene expression of multicellular organisms. Prior research links the …