Glucocorticoids regulate fundamental processes of the human body and control cellular
functions such as cell metabolism, growth, differentiation, and apoptosis. Moreover …

Transcription factors (TFs) are commonly deregulated in the pathogenesis of human cancer
and are a major class of cancer cell dependencies. Consequently, targeting of TFs can be …

Unlike other steroid hormone receptors, the glucocorticoid receptor (GR) is not considered
an oncogene. In breast cancer, the estrogen receptor (ER) drives cell growth, proliferation …

The BH3-only Bim protein is a major determinant for initiating the intrinsic apoptotic pathway
under both physiological and pathophysiological conditions. Tight regulation of its …

While outcomes for children with T-cell acute lymphoblastic leukemia (T-ALL) have
improved dramatically, survival rates for patients with relapsed/refractory disease remain …

Cytokine storm syndromes (CSS) are severe hyperinflammatory conditions characterized by
excessive immune system activation leading to organ damage and death. Hemophagocytic …

Abstract Venetoclax (ABT-199), a specific inhibitor of the anti-apoptotic protein Bcl-2, is
currently in phase I clinical trials for multiple myeloma. The results suggest that venetoclax is …

Background Pediatric acute lymphoblastic leukemia (ALL) is the most common childhood
cancer and the leading cause of cancer-related mortality in children. T cell ALL (T-ALL) …

Abstract (Patho-) physiological activation of the IL7-receptor (IL7R) signaling contributes to
steroid resistance in pediatric T-cell acute lymphoblastic leukemia (T-ALL). Here, we show …

Resistance to glucocorticoids (GC) is associated with an increased risk of relapse in B-cell
progenitor acute lymphoblastic leukemia (BCP-ALL). Performing transcriptomic and single …