The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …

Non-muscle myosin II (NM II) is an actin-binding protein that has actin cross-linking and
contractile properties and is regulated by the phosphorylation of its light and heavy chains …

Myosins are a large family of actin-based cytoskeletal motors that use energy derived from
ATP hydrolysis to generate movement and force. Myosins of classes II, V and VI have …

Members of the nonmuscle myosin-2 (NM-2) family of actin-based molecular motors
catalyze the conversion of chemical energy into directed movement and force thereby acting …

Nonmuscle myosin IIs (NM IIs) are a group of molecular motors involved in a wide variety of
cellular processes including cytokinesis, migration, and control of cell morphology. There …

Metastasis is complex, involving multiple genetic, epigenetic, biochemical, and physical
changes in the cancer cell and its microenvironment. Cells with metastatic potential are often …

Three different genes each located on a different chromosome encode the heavy chains of
nonmuscle myosin II in humans and mice. This review explores the functional …

Class-18 myosins are most closely related to conventional class-2 nonmuscle myosins
(NM2). Surprisingly, the purified head domains of Drosophila, mouse, and human myosin …

Ablation of nonmuscle myosin (NM) II-A or NM II-B results in mouse embryonic lethality.
Here, we report the results of ablating NM II-C as well as NM II-C/II-B together in mice. NM II …

Cells are dynamic systems that generate and respond to forces over a range of spatial and
temporal scales, spanning from single molecules to tissues. Substantial progress has been …