Epigenetic mechanisms play essential roles in determining distinct cell fates during the
development of multicellular organisms. Histone proteins represent crucial epigenetic …

Old and newly synthesized centrosomes have different microtubule nucleating abilities and
they contribute to cell polarity when they migrate to opposite poles during cell division. The …

Label-retaining cells (LRCs) have been proposed to represent adult tissue stem cells. LRCs
are hypothesized to result from either slow cycling or asymmetric cell division (ACD) …

Adult stem cells continuously supply differentiated cells throughout the life of organisms.
This increases the risk of replicative senescence or neoplastic transformation due to …

Adult stem cells maintain the mature tissues of metazoans. They do so by reproducing in
such a way that their progeny either differentiate, and thus contribute functionally to a tissue …

It has long been known that epigenetic changes are inheritable. However, except for DNA
methylation, little is known about the molecular mechanisms of epigenetic inheritance. Many …

Asymmetric cell division (ACD) produces daughter cells with separate distinct cell fates and
is critical for the development and regulation of multicellular organisms. Epigenetic …

We investigated the properties of clonally-expanded mouse hair follicle stem cells (HF-SCs)
in culture. The expansion method, suppression of asymmetric cell kinetics (SACK), is non …

Asymmetric inheritance of sister chromatids has long been predicted to be linked to
discordant fates of daughter cells and even hypothesized to minimize accumulation of …

The semi-conservative nature of DNA replication has suggested that identical DNA
molecules within chromatids are inherited by daughter cells after cell division. Numerous …