Autophagy-dependent cell death can be defined as cell demise that has a strict requirement
of autophagy. Although autophagy often accompanies cell death following many toxic …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Autophagy influences cell survival through maintenance of cell bioenergetics and clearance
of protein aggregates and damaged organelles. Several lines of evidence indicate that …

Over the past two decades, the molecular machinery that underlies autophagic responses
has been characterized with ever increasing precision in multiple model organisms …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable
manner, as a result of their immediate structural breakdown. Such an unavoidable variant of …

Programmed cell death (PCD) is a collective term for diverse processes causing an actively
induced, tightly controlled cellular suicide. PCD has a multitude of functions in the …

Autophagy serves a dichotomous role in cancer and recent advances have helped delineate
the appropriate settings where inhibiting or promoting autophagy may confer therapeutic …

The evolutionarily conserved catabolic process of autophagy involves the degradation of
cytoplasmic components through lysosomal enzymes. Basal levels of autophagy maintain …

Autophagy plays a pivotal role in physiology and pathophysiology, including cancer.
Mechanisms of autophagy dysregulation in cancer remain elusive. Loss of function of …