In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …

Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature
myeloid cells with immunosuppressive effects, which undergo massive expansion during …

Despite the remarkable success of immune checkpoint inhibitors (ICIs) in melanoma
treatment, resistance to them remains a substantial clinical challenge. Myeloid-derived …

Myeloid-derived suppressor cells (MDSC) are generated during tumor progression and
suppress the anti-tumor functions of T and natural killer (NK) cells. Their enrichment is …

Immune checkpoint inhibitors (ICI) used for cancer immunotherapy were shown to boost the
existing anti-tumor immune response by preventing the inhibition of T cells by tumor cells …

Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune
cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after …

Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy typified by a highly
stromal and weakly immunogenic tumor microenvironment that promotes tumor evolution …

The immune system has many sophisticated mechanisms to balance an extensive immune
response. Distinct immunosuppressive cells could protect from excessive tissue damage …

Metastatic spread of tumour cells is the main cause of cancer-related deaths. Understanding
the mechanisms of tumour-cell dissemination has, therefore, become an important focus for …

The immunosuppressive tumor microenvironment represents not only one of the key factors
stimulating tumor progression but also a strong obstacle for efficient tumor immunotherapy …