Lifestyle and metabolic syndrome: contribution of the endocannabinoidome

V Di Marzo, C Silvestri - Nutrients, 2019 - mdpi.com
Lifestyle is a well-known environmental factor that plays a major role in facilitating the
development of metabolic syndrome or eventually exacerbating its consequences. Various …

Colon cancer: from epidemiology to prevention

K Katsaounou, E Nicolaou, P Vogazianos, C Brown… - Metabolites, 2022 - mdpi.com
Colorectal cancer (CRC) is one of the most prevalent cancers affecting humans, with a
complex genetic and environmental aetiology. Unlike cancers with known environmental …

Polyunsaturated fatty acids and endocannabinoids in health and disease

HR Freitas, AR Isaac, R Malcher-Lopes… - Nutritional …, 2018 - Taylor & Francis
Polyunsaturated fatty acids (PUFAs) are lipid derivatives of omega-3 (docosahexaenoic
acid, DHA, and eicosapentaenoic acid, EPA) or of omega-6 (arachidonic acid, ARA) …

The role of the lipid environment in the activity of G protein coupled receptors

R Baccouch, E Rascol, K Stoklosa, ID Alves - Biophysical Chemistry, 2022 - Elsevier
G protein coupled receptors (GPCRs) are a class of membrane proteins that sense
extracellular signals ranging from light to odorants and small molecules and activate …

Multiple endocannabinoid-mediated mechanisms in the regulation of energy homeostasis in brain and peripheral tissues

I Ruiz de Azua, B Lutz - Cellular and molecular life sciences, 2019 - Springer
The endocannabinoid (eCB) system is widely expressed in many central and peripheral
tissues, and is involved in a plethora of physiological processes. Among these, activity of the …

Exploration of multiverse activities of endocannabinoids in biological systems

T Behl, R Makkar, A Sehgal, S Singh… - International Journal of …, 2022 - mdpi.com
Over the last 25 years, the human endocannabinoid system (ECS) has come into the
limelight as an imperative neuro-modulatory system. It is mainly comprised of endogenous …

Ability of high fat diet to induce liver pathology correlates with the level of linoleic acid and Vitamin E in the diet

DS Graham, G Liu, A Arasteh, XM Yin, S Yan - PLoS One, 2023 - journals.plos.org
Increased uptake of fat, such as through the ingestion of high fat diet (HFD), can lead to fatty
liver diseases and metabolic syndrome. It is not clear whether certain fatty acids may be …

[HTML][HTML] The endocannabinoid system: directing eating behavior and macronutrient metabolism

BA Watkins, J Kim - Frontiers in psychology, 2015 - frontiersin.org
For many years, the brain has been the primary focus for research on eating behavior. More
recently, the discovery of the endocannabinoids (EC) and the endocannabinoid system …

The relationship between fatty acids and different depression-related brain regions, and their potential role as biomarkers of response to antidepressants

MF Fernandes, DM Mutch, F Leri - Nutrients, 2017 - mdpi.com
Depression is a complex disorder influenced by a variety of biological and environmental
factors. Due to significant heterogeneity, there are remarkable differences in how patients …

What role does the endocannabinoid system play in the pathogenesis of obesity?

P Schulz, S Hryhorowicz, AM Rychter, A Zawada… - Nutrients, 2021 - mdpi.com
The endocannabinoid system (ECS) is an endogenous signaling system formed by specific
receptors (cannabinoid type 1 and type 2 (CB1 and CB2)), their endogenous ligands …