ABSTRACT Introduction: Quality by design (QbD) encourages the pharmaceutical industry
to use risk management and science-based manufacturing principles to gain process and …

Hydrogel-based drug delivery systems are of interest to researchers for many reasons, such
as biocompatibility, high diversity, and the possibility of administration from different routes …

The problem of many gastroretentive systems is the mechanistic connection of drug release
and gastric retention control. This connection could be successfully separated by formulating …

Super porous hydrogels were developed to retain the drug within intestinal PH which
expand rapidly in the gastric region together with its characteristics for longer time while …

Central composite designs (CCD) are very efficient response surface designs which provide
information exclusively on the effect of experiment variables and overall experimental error …

The present research work describes the systematic development and characterization of
novel gastroretentive drug delivery system containing superporous hydrogel composites for …

For decades, pharmaceutical drug product development has been carried out using the
traditional hit and trial approaches, which are considered to be less efficient and reliable for …

Abstract Taguchi and Plackett–Burman designs are the low-resolution screening
experimental designs which provide excellent information about the influential factors in an …

The development of formulations based on prolongation of gastric residence has been
gaining significant attention of the researchers. The stomach is a major organ of the …

The response surface methodology (RSM) requires high-resolution designs which are
particularly useful for the optimization purpose. It is now considered as an integral …