[HTML][HTML] The disulfiram/copper complex induces autophagic cell death in colorectal cancer by targeting ULK1

Y Hu, Y Qian, J Wei, T Jin, X Kong, H Cao… - Frontiers in …, 2021 - frontiersin.org
Colorectal cancer (CRC) is highly prevalent worldwide, but there has been limited
development of efficient and affordable treatment. Induced autophagy has recently been …

Beneficial effects of metformin treatment on memory impairment

M Pourfridoni, M Hedayati-Moghadam, S Fathi… - Molecular Biology …, 2024 - Springer
Memory issues are a prevalent symptom in different neurodegenerative diseases and can
also manifest in certain psychiatric conditions. Despite limited medications approved for …

[HTML][HTML] α5GABAA Receptor: A Potential Therapeutic Target for Perioperative Neurocognitive Disorders, a Review of Preclinical Studies

Y Xin, T Chu, S Zhou, A Xu - Brain Research Bulletin, 2023 - Elsevier
Perioperative neurocognitive disorders (PND) are a common complication in elderly patients
following surgery, which not only prolongs the recovery period but also affects their future …

Effect of metformin in hypothalamic astrocytes from an immunocompromised mice model

LD Bobermin, DS da Costa, ADM de Moraes… - Biochimie, 2024 - Elsevier
Astrocytes are glial cells that play key roles in neuroinflammation, which is a common
feature in diabetic encephalopathy and aging process. Metformin is an antidiabetic …

[HTML][HTML] Effects of smart drugs on cholinergic system and non-neuronal acetylcholine in the mouse hippocampus: Histopathological approach

R Satoh, K Kawakami, K Nakadate - Journal of Clinical Medicine, 2022 - mdpi.com
In recent years, people in the United States and other countries have been using smart
drugs, called nootropic or cognitive enhancers, to improve concentration and memory …

Piracetam mitigates nephrotoxicity induced by cisplatin via the AMPK-mediated PI3K/Akt and MAPK/JNK/ERK signaling pathways

AM El-Dessouki, AA Alzokaky, NA Raslan… - International …, 2024 - Elsevier
Aims Cisplatin (CDDP) is commonly employed as an antineoplastic agent, but its use is
significantly limited by the occurrence of dose-dependent nephrotoxicity, the detailed …

Research progress on the effects and mechanisms of anesthetics on neural stem cells

J Zhang, QY Chang, L Rizzello, Y Wu - Ibrain, 2022 - Wiley Online Library
Exposure to anesthetic drugs has been proven to seriously affect developing animals in
terms of neural stem cells'(NSCs') proliferation, differentiation, and apoptosis. This can …

[PDF][PDF] Biomarkers, Pandemics and Host Response Treatment

D Fedson - J Nur Healthcare, 2024 - opastpublishers.com
Biomarkers for the COVID-19 pandemic and other forms of severe critical illness are
beneficially affected by generic drugs–statins, ACE inhibitors, angiotensin receptor blockers …