Lung cancer has the highest mortality rate of all cancers worldwide. Lung cancer is a very
heterogeneous disease that is often diagnosed at later stages which have a poor prognosis …

Receptor tyrosine kinases (RTKs) belong to a family of transmembrane receptors that
display tyrosine kinase activity and trigger the activation of downstream signalling pathways …

Alternative splicing plays a major role in regulating the functional repertoire of the proteome.
However, isoform-specific effects to protein-protein interactions (PPIs) are usually …

Four new series 7a-e, 8a-e, 9a-e, and 10a-e of 7-aryl-3-substituted pyrazolo [1, 5-a]
pyrimidines were synthesized and tested for their RTK and STK inhibitory activity …

The most frequent epidermal growth factor receptor (EGFR) mutations found by traditional or
comprehensive molecular profiling of lung adenocarcinomas include indels of exon 19 (the …

ALK rearrangement is called the 'diamond mutation'in non‐small cell lung cancer (NSCLC).
Accurately identifying patients who are candidates for ALK inhibitors is a key step in making …

Despite intensive multimodal treatment of sarcomas, a heterogeneous group of malignant
tumors arising from connective tissue, survival remains poor. Candidate-based targeted …

Splicing quantitative trait loci (sQTLs) have been demonstrated to contribute to disease
etiology by affecting alternative splicing. However, the role of sQTLs in the development of …

Introduction Anaplastic lymphoma kinase (ALK) rearranged lung adenocarcinomas are
responsive to the multitargeted ALK inhibitor crizotinib. One of the common mechanisms of …

To investigate the functional differences of angiopoietin-related protein 4 (ANGPTL4)
transcripts in hepatocellular carcinoma (HCC) cells. By transfecting ANGPTL4-Transcript 1 …