Liver sinusoidal endothelial cells (LSECs) line the low shear, sinusoidal capillary channels
of the liver and are the most abundant non-parenchymal hepatic cell population. LSECs do …

The liver is a central immunological organ with a high exposure to circulating antigens and
endotoxins from the gut microbiota, particularly enriched for innate immune cells …

The liver is an essential organ that is critical for the removal of toxins, the production of
proteins, and the maintenance of metabolic homeostasis. Behind each liver functional unit …

The liver is a tolerogenic organ with exquisite mechanisms of immune regulation that ensure
upkeep of local and systemic immune tolerance to self and foreign antigens, but that is also …

During the onset of liver fibrosis, capillarized liver sinusoidal endothelial cells (LSECs) limit
substance exchange between the blood and the Disse space, further accelerating hepatic …

Background & Aims CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) have a profound ability
to control immune responses. We have previously shown that the liver is a major source of …

Liver sinusoidal endothelial cells (LSECs) line the liver sinusoids and separate passenger
leukocytes in the sinusoidal lumen from hepatocytes. LSECs further act as a platform for …

Antigen-specific immunity requires regulated trafficking of T cells in and out of diverse
tissues in order to orchestrate lymphocyte development, immune surveillance, responses …

This update focuses on two main topics. First, recent developments in our understanding of
liver sinusoidal endothelial cell (LSEC) function will be reviewed, specifically elimination of …

Background & Aims It is well-known that the liver can induce immune tolerance, yet this
knowledge could, thus far, not be translated into effective treatments for autoimmune …