Bloodstream infections: mechanisms of pathogenesis and opportunities for intervention

CL Holmes, OR Albin, HLT Mobley… - Nature Reviews …, 2024 - nature.com
Bloodstream infections (BSIs) are common in hospitals, often life-threatening and increasing
in prevalence. Microorganisms in the blood are usually rapidly cleared by the immune …

WGS-based screening of the co-chaperone protein DjlA-induced curved DNA binding protein A (CbpA) from a new multidrug-resistant zoonotic mastitis-causing …

MH Rahman, S Al Azad, MF Uddin, M Farzana… - Molecular Diversity, 2023 - Springer
The research aimed to establish a multidrug-resistant Klebsiella pneumoniae-induced
genetic model for mastitis considering the alternative mechanisms of the DjlA-mediated …

Iron acquisition and siderophore release by carbapenem-resistant sequence type 258 Klebsiella pneumoniae

VI Holden, MS Wright, S Houle, A Collingwood… - MSphere, 2018 - Am Soc Microbiol
Klebsiella pneumonia e is rapidly acquiring resistance to all known antibiotics, including
carbapenems. Multilocus sequence type ST258 (sequence type 258), carrying a gene …

The Serratia marcescens siderophore serratiochelin is necessary for full virulence during bloodstream infection

DR Weakland, SN Smith, B Bell, A Tripathi… - Infection and …, 2020 - Am Soc Microbiol
Serratia marcescens is a bacterium frequently found in the environment, but over the last
several decades it has evolved into a concerning clinical pathogen, causing fatal …

Altered mucosal bacteria and metabolomics in patients with Peutz–Jeghers syndrome

S Wang, GJ Kou, XH Zhao, G Huang, JX Wang, L Tian… - Gut Pathogens, 2024 - Springer
Abstract Background Peutz–Jeghers syndrome (PJS) is a rare genetic disorder
characterized by the development of pigmented spots, gastrointestinal polyps and increased …

Salmonella-induced SIRT1 and SIRT3 are crucial for maintaining the metabolic switch in bacteria and host for successful pathogenesis

D Hajra, RS Rajmani, AD Chaudhary, SK Gupta… - eLife, 2024 - elifesciences.org
Sirtuins are the major players in host immunometabolic regulation. However, the role of
sirtuins in the modulation of the immune metabolism pertaining to salmonellosis is largely …

Production and uptake of distinct endogenous catecholate-type siderophores are required for iron acquisition and virulence in Chromobacterium violaceum

BB Batista, RERS Santos, R Ricci-Azevedo… - Infection and …, 2019 - Am Soc Microbiol
Bacteria use siderophores to scavenge iron from environmental or host sources. The iron
acquisition systems of Chromobacterium violaceum, a ubiquitous environmental bacterium …

In vitro lung epithelial cell model reveals novel roles for Pseudomonas aeruginosa siderophores

D Kang, Q Xu, NV Kirienko - Microbiology Spectrum, 2024 - Am Soc Microbiol
The multidrug-resistant pathogen Pseudomonas aeruginosa is a common nosocomial
respiratory pathogen that continues to threaten the lives of patients with mechanical …

Siderophores: a novel approach to fight antimicrobial resistance

M Ribeiro, M Simões - Pharmaceuticals from Microbes: Impact on Drug …, 2019 - Springer
The increasing bacterial resistance subsequent to antibiotic use has instigated the
development of new and effective antimicrobial strategies. Bacterial iron uptake systems are …