Background Hydroxyurea is an affordable drug that reduces vaso-occlusive crises and
transfusion requirements in sickle cell disease. However, its effectiveness in preventing …

Background Among individuals with sickle cell disease (SCD), decreased hemoglobin is
associated with lower oxygen saturation (SpO2) and increased risk of stroke, both of which …

Study objectives Compared to typically developing children and young adults (CYA-TD),
those living with Sickle Cell Disease (CYA-SCD) experience more cognitive difficulties …

Research in sickle cell anemia (SCA) has used, with limited race-matched control data,
binary categorization of patients according to the presence or absence of silent cerebral …

Sickle cell disease (SCD) is characterized by chronic hemolytic anemia associated with
impaired cerebral hemodynamics and oxygen metabolism. Hematopoietic stem cell …

Objective Risk for neurocognitive deficits in sickle cell disease (SCD) is well established, yet
minimal research has evaluated the risk for deficits in adaptive functioning. We assessed …

Sickle cell disease (SCD) decreases the oxygen-carrying capacity of red blood cells.
Children with SCD have reduced/restricted cerebral blood flow, resulting in neurocognitive …

Introduction Sickle cell disease (SCD) is a chronic condition with progressive neurocognitive
deficits. Health literacy (HL) is essential during adolescence and young adulthood, as the …

Nonadherence is common in individuals with sickle cell disease (SCD) on hydroxyurea
therapy and can be observed with waning improvements in hematologic parameters or …

Children with sickle cell disease (SCD) may experience cognitive difficulties, including
slowed processing speed. Thus, we investigated if processing speed changes over time …