Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications
YH Chung, H Cai, NF Steinmetz - Advanced Drug Delivery Reviews, 2020 - Elsevier
Viral nanoparticles (VNPs) encompass a diverse array of naturally occurring nanomaterials
derived from plant viruses, bacteriophages, and mammalian viruses. The application and …
derived from plant viruses, bacteriophages, and mammalian viruses. The application and …
[HTML][HTML] The clinical promise of biomarkers of synapse damage or loss in Alzheimer's disease
Background Synapse damage and loss are fundamental to the pathophysiology of
Alzheimer's disease (AD) and lead to reduced cognitive function. The goal of this review is to …
Alzheimer's disease (AD) and lead to reduced cognitive function. The goal of this review is to …
Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons
S Moonen, MJ Koper, E Van Schoor… - Acta …, 2023 - Springer
The major neuropathological hallmarks of Alzheimer's disease (AD) are amyloid β (Aβ)
plaques and neurofibrillary tangles (NFT), accompanied by neuroinflammation and neuronal …
plaques and neurofibrillary tangles (NFT), accompanied by neuroinflammation and neuronal …
[HTML][HTML] Retinal pathological features and proteome signatures of Alzheimer's disease
Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory
retina. However, their exact nature and topographical distribution, particularly in the early …
retina. However, their exact nature and topographical distribution, particularly in the early …
Crosstalk between mitochondrial dysfunction, oxidative stress, and age related neurodegenerative disease: Etiologies and therapeutic strategies
Mitochondrial function is vital for normal cellular processes. Mitochondrial damage and
oxidative stress have been greatly implicated in the progression of aging, along with the …
oxidative stress have been greatly implicated in the progression of aging, along with the …
[HTML][HTML] Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia
We describe in vivo follow-up PET imaging and postmortem findings from an autosomal
dominant Alzheimer's disease (ADAD) PSEN1 E280A carrier who was also homozygous for …
dominant Alzheimer's disease (ADAD) PSEN1 E280A carrier who was also homozygous for …
[HTML][HTML] Rainwater Charitable Foundation criteria for the neuropathologic diagnosis of progressive supranuclear palsy
Neuropathologic criteria for progressive supranuclear palsy (PSP) proposed by a National
Institute of Neurological Disorders and Stroke (NINDS) working group were published in …
Institute of Neurological Disorders and Stroke (NINDS) working group were published in …
Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation
Amyloid-β, a hallmark of Alzheimer's disease, begins accumulating up to two decades
before the onset of dementia, and can be detected in vivo applying amyloid-β positron …
before the onset of dementia, and can be detected in vivo applying amyloid-β positron …
[HTML][HTML] Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer's disease and PART
SK Kaufman, K Del Tredici, TL Thomas, H Braak… - Acta …, 2018 - Springer
Alzheimer's disease (AD) is characterized by accumulation of tau neurofibrillary tangles
(NFTs) and, according to the prion model, transcellular propagation of pathological “seeds” …
(NFTs) and, according to the prion model, transcellular propagation of pathological “seeds” …
[HTML][HTML] Identification of early pericyte loss and vascular amyloidosis in Alzheimer's disease retina
Pericyte loss and deficient vascular platelet-derived growth factor receptor-β (PDGFRβ)
signaling are prominent features of the blood–brain barrier breakdown described in …
signaling are prominent features of the blood–brain barrier breakdown described in …