Tissue‐derived decellularized extracellular matrix (dECM) provides unique biomolecular
cues for bioengineering 3D tumor models with increasingly physiomimetic features. This …

In vitro cell culture studies are common in the cancer research field, and reliable biomimetic
3D models are needed to ensure physiological relevance. In this manuscript, we …

The desmoplastic bioarchitecture and microenvironment caused by fibroblasts have been
confirmed to be closely related to the drug response behavior of pancreatic ductal …

Abstract 3D cancer cell cultures have enabled new opportunities for replacing compound
testing in experimental animals. However, most solid tumors are composed of multiple cell …

Mechanical force exerted on cancer cells by their microenvironment have been reported to
drive cells toward invasive phenotypes by altering cells' motility, proliferation, and apoptosis …

Remodeling (re-engineering) of a tumor's stroma can improve the efficacy of antitumor
therapies, without destroying the stroma. However, it still remains elusive how the …

Pancreatic cancer is one of the deadliest cancers to treat. The primary cause for the drug
resistance is the dense extracellular matrix (ECM) that surrounds the tumor and restricts …

Pancreatic ductal adenocarcinoma (PDAC) is characterised by a rich fibrotic stroma, which
stems from the overproduction of extracellular matrix (ECM), resulting from the cancerstroma …