Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high
personal and societal burden. Exposure to toxic particles and gases, including cigarette …

Neutrophilic inflammation has a key role in the pathophysiology of multiple chronic lung
diseases. The formation of neutrophil extracellular traps (NETs) has emerged as a key …

Background Chronic obstructive pulmonary disease (COPD) is characterized by chronic
bronchitic and emphysematous components. In one biophysical model, the concentration of …

Background Neutrophil extracellular traps (NETs) have been observed in the airway in
patients with chronic obstructive pulmonary disease (COPD), but their clinical and …

The current epidemic of chronic obstructive pulmonary disease (COPD) has produced a
worldwide health care burden, approaching that imposed by transmittable infectious …

Several studies have recently identified strong epigenetic signals related to tobacco
smoking. However, an aspect that did not receive much attention is the evolution of …

The pathogenesis of chronic obstructive pulmonary disease (COPD) is based on the innate
and adaptive inflammatory immune response to the inhalation of toxic particles and gases …

DNA hypomethylation in certain genes is associated with tobacco exposure but it is
unknown whether these methylation changes translate into increased lung cancer risk. In an …

Chronic obstructive pulmonary disease (COPD) is a major incurable global health burden
and is currently the 4th largest cause of death in the world. Importantly, much of the disease …

One hundred million deaths were caused by tobacco in the 20th century, and it is estimated
that there will be up to one billion deaths attributed to tobacco use in the 21st century …