Novel and effective antiseizure medications are needed to treat refractory and rare forms of
epilepsy. Cannabinoids, which are obtained from the cannabis plant, have a long history of …

Despite being regarded as a hippie science for decades, cannabinoid research has finally
found its well-deserved position in mainstream neuroscience. A series of groundbreaking …

The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …

Recent advances in the understanding of brain cannabinoid receptor function have renewed
interest in the association between cannabinoid compounds and psychosis. In a 3-day …

Freund, Tamás F., István Katona, and Daniele Piomelli. Role of Endogenous Cannabinoids
in Synaptic Signaling. Physiol Rev 83: 1017–1066, 2003; 10.1152/physrev. 00004.2003 …

The primary psychoactive ingredient in cannabis, Δ9-tetrahydrocannabinol (Δ9-THC), affects
the brain mainly by activating a specific receptor (CB1). CB1 is expressed at high levels in …

CB 1 cannabinoid receptors appear to mediate most, if not all of the psychoactive effects of
delta-9-tetrahydrocannabinol and related compounds. This G protein-coupled receptor has …

The active compound in herbal cannabis, Δ9‐tetrahydrocannabinol, exerts all of its known
central effects through the CB1 cannabinoid receptor. Research on cannabinoid …

During the last few years, the endocannabinoid system has emerged as a highly relevant
topic in the scientific community. Many different regulatory actions have been attributed to …

In the case of the cannabinoid receptor, the lack of potent antagonists has been a limiting
factor in defining cannabinoid receptor-mediated responses. Several lines of evidence …