This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …

The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

The intestinal epithelial monolayer forms a transcellular and paracellular barrier that
separates luminal contents from the interstitium. The paracellular barrier consists of a highly …

Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

Baking soda and vinegar have been used as home remedies for generations and today we
are only a mouse-click away from claims that baking soda, lemon juice, and apple cider …

Metabolic adaptations are intimately associated with changes in cell behavior. Cancers are
characterized by a high metabolic plasticity resulting from mutations and the selection of …

Melanomas are metabolically heterogeneous, and they are able to adapt in order to utilize a
variety of fuels that facilitate tumor progression and metastasis. The significance of …

Inflammatory bowel diseases broadly categorized into Crohn's disease (CD) and ulcerative
colitis (UC), are chronic inflammatory disorders of the gastrointestinal tract with increasing …

The human solute carriers (SLCs) comprise over 400 different transporters, organized into
65 families (http://slc. bioparadigms. org/) based on their sequence homology and transport …

Intracellular pH (pHi) regulation in the brain is important in both physiological and
physiopathological conditions because changes in pHi generally result in altered neuronal …