Pathogenic mechanisms in HBV-and HCV-associated hepatocellular carcinoma
A Arzumanyan, HM Reis, MA Feitelson - Nature Reviews Cancer, 2013 - nature.com
Hepatocellular carcinoma (HCC) is a highly lethal cancer, with increasing worldwide
incidence, that is mainly associated with chronic hepatitis B virus (HBV) and/or hepatitis C …
incidence, that is mainly associated with chronic hepatitis B virus (HBV) and/or hepatitis C …
The enigmatic X gene of hepatitis B virus
MJ Bouchard, RJ Schneider - Journal of virology, 2004 - Am Soc Microbiol
With an estimate of 350 million people chronically infected with the hepatitis B virus (HBV)
worldwide, it is critically important to understand how persistent HBV infection is maintained …
worldwide, it is critically important to understand how persistent HBV infection is maintained …
[PDF][PDF] Angiogenesis in chronic inflammatory liver disease
J Medina, AG Arroyo, F Sánchez‐Madrid… - …, 2004 - Wiley Online Library
Intrahepatic hypoxia may occur during the inflammatory and fibrotic processes that
characterize several chronic liver diseases of viral and autoimmune origin. As a …
characterize several chronic liver diseases of viral and autoimmune origin. As a …
[PDF][PDF] Hepatitis B virus X protein is essential for the activation of Wnt/β‐catenin signaling in hepatoma cells
Wnt/β‐catenin signaling contributes to diverse cellular functions, such as Drosophila wing
development and colon carcinogenesis. Recently, stabilizing mutations of β‐catenin, a …
development and colon carcinogenesis. Recently, stabilizing mutations of β‐catenin, a …
The direct and indirect roles of HBV in liver cancer: prospective markers for HCC screening and potential therapeutic targets
M Ringelhan, T O'Connor, U Protzer… - The Journal of …, 2015 - Wiley Online Library
Chronic hepatitis B virus (HBV) infection remains the number one risk factor for
hepatocellular carcinoma (HCC), accounting for more than 600 000 deaths/year. Despite …
hepatocellular carcinoma (HCC), accounting for more than 600 000 deaths/year. Despite …
Hepatitis B virus X protein: molecular functions and its role in virus life cycle and pathogenesis
S Benhenda, D Cougot, MA Buendia… - Advances in cancer …, 2009 - Elsevier
Despite the existence of effective vaccines, HBV infection remains a major health problem
with 2 billion people infected worldwide. Among them, 350 million are chronically infected, a …
with 2 billion people infected worldwide. Among them, 350 million are chronically infected, a …
The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression
E Lara-Pezzi, MV Gómez-Gaviro… - The Journal of …, 2002 - Am Soc Clin Investig
Hepatocellular carcinoma is strongly associated with chronic infection by the hepatitis B
virus (HBV) and has poor prognosis due to intrahepatic metastasis. HBx is often the only …
virus (HBV) and has poor prognosis due to intrahepatic metastasis. HBx is often the only …
Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1
E-cadherin is a key cell adhesion molecule implicated as a tumor suppressor, which is
frequently altered in hepatocellular carcinoma, especially in hepatitis B virus (HBV)-related …
frequently altered in hepatocellular carcinoma, especially in hepatitis B virus (HBV)-related …
The HBV web: An insight into molecular interactomes between the hepatitis B virus and its host en route to hepatocellular carcinoma
A Kar, A Samanta, S Mukherjee… - Journal of Medical …, 2023 - Wiley Online Library
Hepatitis B virus (HBV) is a major aetiology associated with the development and
progression of hepatocellular carcinoma (HCC), the most common primary liver malignancy …
progression of hepatocellular carcinoma (HCC), the most common primary liver malignancy …
Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells
Expression level of metastasis-associated protein 1 (MTA1) is closely related to tumor
growth and metastasis in various cancers. Although increased expression level of MTA1 …
growth and metastasis in various cancers. Although increased expression level of MTA1 …