Older people often show auditory temporal processing deficits and speech-in-noise
intelligibility difficulties even when their audiogram is clinically normal. The causes of such …

The older listener's ability to understand speech in challenging environments may be
affected by impaired temporal processing. This review summarizes objective evidence of …

In social settings, speech waveforms from nearby speakers mix together in our ear canals.
Normally, the brain unmixes the attended speech stream from the chorus of background …

Auditory de-afferentation, a permanent reduction in the number of inner-hair-cells and
auditory-nerve synapses due to cochlear damage or synaptopathy, can reliably be …

Animal studies have demonstrated that noise exposure can lead to the loss of the synapses
between the inner hair cells and their afferent auditory nerve fiber targets without impacting …

The envelope following response (EFR) has been proposed as a non-invasive marker of
synaptopathy in animal models. However, its amplitude is affected by the spread of basilar …

Recent studies have found that envelope following responses (EFRs) are a marker of age-
related and noise-or ototoxic-induced cochlear synaptopathy (CS) in research animals …

Linearized encoding models are increasingly employed to model cortical responses to
running speech. Recent extensions to subcortical responses suggest clinical perspectives …

Aging, noise exposure, and ototoxic medications lead to cochlear synapse loss in animal
models. As cochlear function is highly conserved across mammalian species, synaptopathy …

Hearing loss affects approximately 18% of the population worldwide. Hearing difficulties in
noisy environments without accompanying audiometric threshold shifts likely affect an even …