Prevalence and factors associated with multidrug-resistant tuberculosis in South India

SS Shivekar, V Kaliaperumal, U Brammacharry… - Scientific reports, 2020 - nature.com
India accounts for about one-fourth of the global burden of MDR-TB. This study aims to
assess the prevalence and factors associated with tuberculosis drug resistance among …

The pathogenic mechanism of Mycobacterium tuberculosis: implication for new drug development

W Yan, Y Zheng, C Dou, G Zhang, T Arnaout… - Molecular …, 2022 - Springer
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a tenacious
pathogen that has latently infected one third of the world's population. However …

Mutations in rpoB That Confer Rifampicin Resistance Can Alter Levels of Peptidoglycan Precursors and Affect β-Lactam Susceptibility

Y Patel, V Soni, KY Rhee, JD Helmann - MBio, 2023 - Am Soc Microbiol
Bacteria can adapt to stressful conditions through mutations affecting the RNA polymerase
core subunits that lead to beneficial changes in transcription. In response to selection with …

Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism

J Peek, M Lilic, D Montiel, A Milshteyn… - Nature …, 2018 - nature.com
Rifamycin antibiotics (Rifs) target bacterial RNA polymerases (RNAPs) and are widely used
to treat infections including tuberculosis. The utility of these compounds is threatened by the …

Isatin-pyrimidine hybrid derivatives as enoyl acyl carrier protein reductase (InhA) inhibitors against Mycobacterium tuberculosis

A Khalifa, A Khalil, MM Abdel-Aziz, A Albohy… - Bioorganic …, 2023 - Elsevier
Tuberculosis is a worldwide problem that impose a burden on the economy due to
continuous development of resistant strains. The development of new antitubercular drugs is …

Identification of new anti-mycobacterial agents based on quinoline-isatin hybrids targeting enoyl acyl carrier protein reductase (InhA)

EF Khaleel, A Sabt, M Korycka-Machala, RM Badi… - Bioorganic …, 2024 - Elsevier
Tuberculosis (TB) is a global issue that poses a significant economic burden as a result of
the ongoing emergence of drug-resistant strains. The urgent requirement for the …

Identification of 2-(N-aryl-1,2,3-triazol-4-yl) quinoline derivatives as antitubercular agents endowed with InhA inhibitory activity

A Sabt, MH Abdulla, MS Ebaid, J Pawełczyk… - Frontiers in …, 2024 - frontiersin.org
The spread of drug-resistant tuberculosis strains has become a significant economic burden
globally. To tackle this challenge, there is a need to develop new drugs that target specific …

Phenotypic drug susceptibility characterization and clinical outcomes of tuberculosis strains with A-probe mutation by GeneXpert MTB/RIF

Q Nie, D Sun, M Zhu, S Tu, N Chen, H Chen… - BMC Infectious …, 2023 - Springer
Abstract Background GeneXpert MTB/RIF (Xpert) assay was applied widely to detect
Mycobacterium tuberculosis (MTB) and rifampicin resistance. Methods Retrospectively …

Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis

A Munir, MT Wilson, SW Hardwick, DY Chirgadze… - Structure, 2021 - cell.com
Resolution advances in cryoelectron microscopy (cryo-EM) now offer the possibility to
visualize structural effects of naturally occurring resistance mutations in proteins and also of …

[HTML][HTML] Frequency and patterns of first-and second-line drug resistance-conferring mutations in Mycobacterium tuberculosis isolated from pulmonary tuberculosis …

LN Welekidan, E Skjerve, TA Dejene… - Journal of Global …, 2021 - Elsevier
Objectives Tuberculosis (TB) is a preventable and treatable infectious disease, but the
continuing emergence and spread of multidrug-resistant TB is threatening global TB control …