In the drug discovery setting, undesirable ADMET properties of a pharmacophore with good
predictive power obtained after a tedious drug discovery and development process may …

Thiazole derivatives remains honored heterocycles in the field of medicinal chemistry. This
scaffold has been proven as a universal motif that is present in numerous pharmacologically …

A series of new pyrazolo-benzothiazole hybrids (7–26) were synthesised and screened for
their cytotoxic activity towards several cancer cell lines [colon (HT-29), prostate (PC-3), lung …

In this work, the binding affinity of fanetizole with proteases pepsin and trypsin were
investigated by spectroscopy and molecular docking. As a thiazole derivative, the …

In the present study, a novel series of azo-thiazole derivatives (3a–c) containing a thiazole
moiety was successfully synthesized. The structure of these derivatives was examined by …

Heterocyclic rings such as thiazole and benzimidazole are considered as privileged
structures, since they constitute several FDA-approved drugs for cancer treatment. In this …

Thiazoles have attracted much synthetic interest due to their wide variety of biological
properties and are important members of heterocyclic compounds. In recent years, studies …

Fluorine-containing heterocycles continue to receive considerable attention due to their
unique properties. In medicinal chemistry, the incorporation of fluorine in small molecules …

Background Thiazole ring is one of the most important heterocycle scaffolds in organic and
medicinal chemistry due to this scaffold being the backbone of numerous drugs and their …

New benztriazoles with a mercapto-triazole and other heterocycle substituents were
synthesized and evaluated for their anticonvulsant activity and neurotoxicity by using the …